A manganese photosensitive tricarbonyl molecule [Mn(CO)3(tpa-κ3N)]Br enhances antibiotic efficacy in a multi-drug-resistant Escherichia coli

N Rana, HE Jesse, M Tinajero-Trejo… - …, 2017 - microbiologyresearch.org
Carbon monoxide-releasing molecules (CORMs) are a promising class of new
antimicrobials, with multiple modes of action that are distinct from those of standard …

Carbon monoxide is a poison… to microbes! CO as a bactericidal molecule

BY Chin, LE Otterbein - Current opinion in pharmacology, 2009 - Elsevier
Inflammation and immunity result in a wide range of disease processes, including chronic
obstructive pulmonary disease, ischemia–reperfusion injury, atherosclerosis, vascular …

A fluorescent ESIPT probe for imaging CO-releasing molecule-3 in living systems

W Feng, S Feng, G Feng - Analytical chemistry, 2019 - ACS Publications
CO-releasing molecule-3 (CORM-3) has been widely used recently as a convenient and
safe CO donor to release exogenous CO in living cells and to study the effects of CO on …

Carbon monoxide-releasing molecules (CO-RMs): vasodilatory, anti-ischaemic and anti-inflammatory activities

R Motterlini - Biochemical Society Transactions, 2007 - portlandpress.com
The well-known adverse effects of CO (carbon monoxide) intoxication are counterbalanced
by its positive actions when small amounts are produced intracellularly by the cytoprotective …

[HTML][HTML] Gasotransmitters, poisons, and antimicrobials: it's a gas, gas, gas!

M Tinajero-Trejo, HE Jesse, RK Poole - F1000prime reports, 2013 - ncbi.nlm.nih.gov
We review recent examples of the burgeoning literature on three gases that have major
impacts in biology and microbiology. NO, CO and H 2 S are now co-classified as …

Chemistry and biological activities of CO-releasing molecules (CORMs) and transition metal complexes

R Alberto, R Motterlini - Dalton Transactions, 2007 - pubs.rsc.org
The advent of CO as a small molecule that, in addition to NO, elicits essential biological
functions has initiated the search for compounds and complexes capable of releasing CO in …

Visible‐Light‐Induced CO Release from a Therapeutically Viable Tryptophan‐Derived Manganese (I) Carbonyl (TryptoCORM) Exhibiting Potent Inhibition against E …

JS Ward, JM Lynam, J Moir… - Chemistry–A European …, 2014 - Wiley Online Library
The first visible‐light‐activated carbon‐monoxide‐releasing molecule (CO‐RM) to exhibit a
potent effect against Escherichia coli is described. The easily prepared tryptophan‐derived …

Strategies toward organic carbon monoxide prodrugs

X Ji, B Wang - Accounts of Chemical Research, 2018 - ACS Publications
Conspectus Carbon monoxide is widely acknowledged as an important gasotransmitter in
the mammalian system with importance on par with that of nitric oxide. It has also been firmly …

Generation of carbon monoxide releasing molecules (CO-RMs) as drug candidates for the treatment of acute liver injury: targeting of CO-RMs to the liver

AR Marques, L Kromer, DJ Gallo, N Penacho… - …, 2012 - ACS Publications
The discovery of the biological effects of carbon monoxide (CO) in recent years strongly
suggests that CO could find applications as a therapeutic agent. CO is a highly toxic gas …

CO–metal interaction: vital signaling from a lethal gas

J Boczkowski, JJ Poderoso, R Motterlini - Trends in biochemical sciences, 2006 - cell.com
The past few years have witnessed intense research into the biological significance of
carbon monoxide (CO) as an essential signaling mediator in cells and tissues. To transduce …