Objective: There is an association between frailty and arterial stiffness. However, arterial
stiffness does not uniformly correlate with the spectrum of frailty states. Both oxidative stress …

Background Frailty is a risk factor for cardiovascular disease (CVD). Underlying mechanisms
to explain the connection between frailty and CVD are unclear. We sought to examine the …

Explorers like Juan Ponce de León were on a quest to discover the Fountain of Youth to find
a remedy for aging as early as the 16th century. Now, centuries later, advancements in …

Background Frailty is a condition characterized by a state of reduced physiological reserve
and increased vulnerability to stressors. Frail individuals have a higher likelihood of …

Objectives: The new concept about frailty (difference between being functional and
nonfunctional) represents an important issue in the treatment of the elderly. Many recent …

In the last decade, a growing literature raised arterial stiffness as a ''hot topic''in terms of
pathophysiology of cardiovascular (CV) system and clinical relevance [1, 2]. In order to …

Background Inflammation, coagulation activation, endothelial dysfunction and subclinical
vascular disease are cross-sectionally associated with frailty. Cardiac-specific biomarkers …

Purpose Frailty and atherosclerotic diseases are prevalent among the older people and
usually present the same pathogenesis and risk factors. Therefore, the aim of this study was …

Background Physical frailty and sarcopenia (PF & S) are major public health problems in the
older population and promising predictors of adverse cardiovascular outcomes. However …

Frailty and cardiovascular disease share some of the pathophysiologic features. Our
objective was to review and metaanalyse the available published evidence on the topic. We …