Helminth and host crosstalk: new insight into treatment of obesity and its associated metabolic syndromes

M Dai, X Yang, Y Yu, W Pan - Frontiers in immunology, 2022 - frontiersin.org
Obesity and its associated Metabolic Syndromes (Mets) represent a global epidemic health
problem. Metabolic inflammation, lipid accumulation and insulin resistance contribute to the …

Immune regulation of metabolic homeostasis by helminths and their molecules

HJP van der Zande, A Zawistowska-Deniziak… - Trends in …, 2019 - cell.com
Since time immemorial, humans have coevolved with a wide variety of parasitic helminths
that have contributed to shape their immune system. The recent eradication of helminth …

A worm of one's own: how helminths modulate host adipose tissue function and metabolism

B Guigas, AB Molofsky - Trends in parasitology, 2015 - cell.com
Parasitic helminths have coexisted with human beings throughout time. Success in
eradicating helminths has limited helminth-induced morbidity and mortality but is also …

Regulation of host metabolic health by parasitic helminths

S Sikder, D Pierce, ER Sarkar, C McHugh… - Trends in …, 2024 - cell.com
Obesity is a worldwide pandemic and major risk factor for the development of metabolic
syndrome (MetS) and type 2 diabetes (T2D). T2D requires lifelong medical support to limit …

The interplay of type 2 immunity, helminth infection and the microbiota in regulating metabolism

M Moyat, G Coakley, NL Harris - Clinical & Translational …, 2019 - Wiley Online Library
Type 2 immunity has recently emerged as a critical player in metabolic status, with
numerous studies investigating the role of type 2 immune cells within adipose tissue …

Helminth infection protects against high fat diet-induced obesity via induction of alternatively activated macrophages

C Su, CY Chen, Y Li, SR Long, W Massey, DV Kumar… - Scientific reports, 2018 - nature.com
Epidemiological studies indicate an inverse correlation between the prevalence of the so-
called western diseases, such as obesity and metabolic syndrome, and the exposure to …

[HTML][HTML] Infections and immunity: associations with obesity and related metabolic disorders

A Ray, MJL Bonorden, R Pandit… - … of Pathology and …, 2023 - synapse.koreamed.org
About one-fourth of the global population is either overweight or obese, both of which
increase the risk of insulin resistance, cardiovascular diseases, and infections. In obesity …

[PDF][PDF] Chronic helminth infection and helminth‐derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice

L Hussaarts, N García‐Tardón, L van Beek… - The FASEB …, 2015 - drive.google.com
Chronic low-grade inflammation associated with obesity contributes to insulin resistance
and type 2 diabetes. Helminth parasites are the strongest natural inducers of type 2 immune …

Helminths, hygiene hypothesis and type 2 diabetes

K De Ruiter, DL Tahapary, E Sartono… - Parasite …, 2017 - Wiley Online Library
Worldwide, there is little overlap between the prevalence of soil‐transmitted helminths and
type 2 diabetes (T2D). Helminth‐induced type 2 immune responses and immune regulatory …

[HTML][HTML] Helminth-induced and Th2-dependent alterations of the gut microbiota attenuate obesity caused by high-fat diet

CW Su, CY Chen, L Jiao, SR Long, T Mao, Q Ji… - Cellular and molecular …, 2020 - Elsevier
Background & Aims Epidemiological and animal studies have indicated an inverse
correlation between the rising prevalence of obesity and metabolic syndrome and exposure …