Opsonization, biodistribution, cellular uptake and apoptosis study of PEGylated PBCA nanoparticle as potential drug delivery carrier

KR Chaudhari, M Ukawala, AS Manjappa… - Pharmaceutical …, 2012 - Springer
Purpose For nanocarrier-based targeted delivery systems, preventing phagocytosis for
prolong circulation half life is a crucial task. PEGylated poly (n-butylcyano acrylate)(PBCA) …

Enhancing anti-cancer efficacy of carboplatin by PEGylated poly (butyl cyanoacrylate) nano-particles

M Hassanzadeganroudsari, A Heydarinasab… - Journal of Drug Delivery …, 2019 - Elsevier
Nano-drug delivery holds great potential to enhance the efficacy of carboplatin. This study
focused on cytotoxicity, in vitro drug release and characterization of poly (butyl …

Cationic albumin conjugated pegylated nanoparticle with its transcytosis ability and little toxicity against blood–brain barrier

W Lu, YZ Tan, KL Hu, XG Jiang - International journal of pharmaceutics, 2005 - Elsevier
Our newly developed drug delivery carrier, cationic bovine serum albumin (CBSA)
conjugated with poly (ethyleneglycol)-poly (lactide)(PEG-PLA) nanoparticle (CBSA-NP), was …

Novel therapeutic approach in PEGylated chitosan nanoparticles of Apigenin for the treatment of cancer via oral nanomedicine

MA Mujtaba, NM Alotaibi, SM Alshehri, M Yusuf… - Polymers, 2022 - mdpi.com
The goal of this study was to optimize and formulate apigenin (APG)-loaded pegylated
chitosan nanoparticles (PEGylated-CNPs) via ionic gelation techniques using the Box …

Brain delivery property and accelerated blood clearance of cationic albumin conjugated pegylated nanoparticle

W Lu, J Wan, Z She, X Jiang - Journal of controlled release, 2007 - Elsevier
Cationic bovine serum albumin (CBSA) conjugated poly (ethyleneglycol)-poly (lactide)(PEG-
PLA) nanoparticle (CBSA-NP), was designed as a novel drug carrier for brain delivery. In …

Tumor micro-environment sensitive release of doxorubicin through chitosan based polymeric nanoparticles: An in-vitro study

MU Akram, N Abbas, M Farman, S Manzoor, MI Khan… - Chemosphere, 2023 - Elsevier
Conventional chemotherapy poses toxic effects to healthy tissues. A therapeutic system is
thus required that can administer, distribute, metabolize, and excrete medicine from human …

Cisplatin-loaded polybutylcyanoacrylate nanoparticles with improved properties as an anticancer agent

SE Alavi, S Muflih Al Harthi… - International Journal of …, 2019 - mdpi.com
This study aims to improve the cytotoxicity and potency of cisplatin-loaded
polybutylcyanoacrylate (PBCA) nanoparticles (NPs) for the treatment of lung cancer through …

Doxorubicin loaded on chitosan-protamine nanoparticles triggers apoptosis via downregulating Bcl-2 in breast cancer cells

MA Abdel-Hakeem, OM Abdel-Haseb… - Journal of Drug Delivery …, 2020 - Elsevier
Cancer-specific drug delivery is a reliable approach to evade undesirable side effects and
increase the bioavailability of the drug in tumor cells. In the present study, we treated breast …

Preparation and characterization of chitosan nanoparticles for chemotherapy of melanoma through enhancing tumor penetration

H Guo, F Li, H Qiu, J Liu, S Qin, Y Hou… - Frontiers in …, 2020 - frontiersin.org
The poor solubility and permeability of most chemotherapeutic drugs lead to unsatisfactory
bioavailability combined with insufficient drug concentration. In this study, positively charged …

Improved delivery of doxorubicin using rationally designed PEGylated platinum nanoparticles for the treatment of melanoma

S Mukherjee, R Kotcherlakota, S Haque… - Materials Science and …, 2020 - Elsevier
Efficient delivery of chemotherapeutic drugs to tumor cells is one of the crucial issues for
modern day cancer therapy. In this article, we report the synthesis of poly ethylene glycol …