Serum tumor necrosis factor activity in inflammatory bowel disease

M Maeda, N Watanabe, H Neda… - …, 1992 - Taylor & Francis
Serum tumor necrosis factor (TNF) levels in 33 patients with inflammatory bowel disease
(IBD) were measured by using a sensitive enzyme immunoassay. Four of five Crohn's …

Circulating and mucosal concentrations of tumour necrosis factor and inhibitor (s) in chronic inflammatory bowel disease.

OH Nielsen, J Brynskov, K Bendtzen - Danish Medical Bulletin, 1993 - europepmc.org
Monokines, in particular the interleukin-1 family and tumour necrosis factor alpha, have
been implicated in the pathogenesis of chronic inflammatory bowel disease. We initially …

Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease.

SH Murch, CP Braegger, JA Walker-Smith… - Gut, 1993 - gut.bmj.com
This study determined the location and tissue density of cells immunoreactive for tumour
necrosis factor alpha (TNF alpha) in intestinal specimens from 24 patients with chronic …

Tumour necrosis factor and Crohn's disease.

SJ Van Deventer - Gut, 1997 - ncbi.nlm.nih.gov
The production of several pro-inflammatory cytokines is increased in inflammatory bowel
diseases (IBD). Experimental models of IBD have further defined the importance of specific …

Tumor necrosis factor (TNF) in inflammatory bowel disease: gene polymorphisms, animal models, and potential for anti-TNF therapy.

PC Stokkers, L Camoglio… - Journal of inflammation, 1995 - europepmc.org
The inflammatory bowel diseases frequently require surgery because of intestinal
complications. Animal models of inflammatory bowel disease, in particular those that …

Cellular localization of tumor necrosis factor (TNF)-alpha transcripts in normal bowel and in necrotizing enterocolitis. TNF gene expression by Paneth cells, intestinal …

X Tan, W Hsueh, F Gonzalez-Crussi - The American journal of …, 1993 - ncbi.nlm.nih.gov
Tumor necrosis factor-alpha (TNF) has been shown to induce intestinal necrosis in animals.
Moreover, plasma TNF levels are elevated in patients with necrotizing enterocolitis. Thus, it …

Intraluminal colonic release of immunoreactive tumour necrosis factor in chronic ulcerative colitis

F Casellas, M Papo, F Guarner, M Antolin… - Clinical …, 1994 - portlandpress.com
1. Tumour necrosis factor is a proinflammatory macrophage-derived polypeptide cytokine. Its
participation in disease processes has been usually inferred from data obtained from …

Tumor necrosis factor-α in serum of patients with inflammatory bowel disease as measured by a highly sensitive immuno-PCR

M Komatsu, D Kobayashi, K Saito, D Furuya… - Clinical …, 2001 - academic.oup.com
Background: The significance of serum concentrations of tumor necrosis factor-α (TNF-α) in
the pathogenesis of inflammatory bowel disease (IBD) is uncertain. We measured TNF-α in …

Serum concentrations of tumour necrosis factor alpha in childhood chronic inflammatory bowel disease.

SH Murch, VA Lamkin, MO Savage, JA Walker-Smith… - Gut, 1991 - gut.bmj.com
Serum tumour necrosis factor alpha (TNF alpha) concentrations were measured by enzyme
linked immunoadsorbent assay in 31 normal children and during 65 episodes of clinical …

Transmembrane tumor necrosis factor is a potent inducer of colitis even in the absence of its secreted form

N Corazza, T Brunner, C Buri, S Rihs, MA Imboden… - Gastroenterology, 2004 - Elsevier
Background & Aims: Tumor necrosis factor (TNF) is cleaved proteolytically from a 26-
kilodalton transmembrane precursor protein into secreted 17-kilodalton monomers …