In the past years, the research on angiogenesis was mostly directed to the definition of the
mechanisms able to modulate vascular growth. We now understand that in many …

Endothelial cell contacts are regulated by a complex interplay between various receptors
and signaling mediators that control the plasticity of the cytoskeleton and the function of …

Endothelial cells (ECs) express 2 members of the cadherin family, VE and N-cadherin.
Although VE-cadherin induces EC homotypic adhesion, N-cadherin function in ECs remains …

The endothelial cell adhesion molecules, neural-and vascular endothelial-cadherin play
essential roles in the formation of stable and fully functional blood vessels. This commentary …

Cell to cell junctions direct endothelial responses both in quiescent and angiogenic vessels.
Endothelial cells express both tight and adherens junctions. Although different in their …

In the present paper, we characterize an antibody, mAb BV13, directed to mouse vascular
endothelial (VE)-cadherin, a major adhesive protein of interendothelial adherens junctions …

Although being a monolayer the vascular endothelium controls fundamental vessel
functions such as permeability, leukocyte extravasation and angiogenesis. The endothelial …

Exchanges between the blood compartment and the surrounding tissues require a tight
regulation by the endothelial barrier. Recent reports inferred that VE-cadherin, an …

Vascular endothelial cadherin (VE-cadherin) is an endothelial-specific, trans-membrane
protein that promotes homophilic cell adhesion. Inhibition of VE-cadherin by the blocking …

In the past years, several studies explored the contribution of various signaling pathways in
the regulation of vascular leakage. Despite encouraging results, a more comprehensive …