MicroRNAs in the search for understanding human diseases

RJ Perera, A Ray - BioDrugs, 2007 - Springer
MiroRNAs (miRNAs) are double-stranded, noncoding RNA molecules (with an average size
of 22bp) that serve as post-transcriptional regulators of gene expression in higher …

[PDF][PDF] SnapShot: unconventional miRNA functions

MP Dragomir, E Knutsen, GA Calin - Cell, 2018 - cell.com
MicroRNAs (miRNAs) are synonymous with post-transcriptional repression of target genes.
A number of studies, however, have reported miRNAs functioning outside this paradigm …

Mechanistic insights into microRNA-mediated gene silencing

TF Duchaine, MR Fabian - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
MicroRNAs (miRNAs) posttranscriptionally regulate gene expression by repressing protein
synthesis and exert a broad influence over development, physiology, adaptation, and …

A guide to micro RNA‐mediated gene silencing

M Quévillon Huberdeau, MJ Simard - The FEBS journal, 2019 - Wiley Online Library
As an important regulator of gene expression in eukaryotes, micro RNA s (mi RNA s) have
been subject to extensive research to understand their pleiotropic roles in development and …

Polymerase II promoter strength determines efficacy of microRNA adapted shRNAs

RJ Lebbink, M Lowe, T Chan, H Khine, X Wang… - PloS one, 2011 - journals.plos.org
Since the discovery of RNAi and microRNAs more than 10 years ago, much research has
focused on the development of systems that usurp microRNA pathways to downregulate …

Lentivirus-mediated antagomir expression for specific inhibition of miRNA function

M Scherr, L Venturini, K Battmer… - Nucleic acids …, 2007 - academic.oup.com
Micro RNAs (miRNA) regulate gene expression by hybridization and recruitment of multi-
protein complexes to complementary mRNA target sequences. miRNA function can …

The impact of miRNA target sites in coding sequences and in 3′ UTRs

Z Fang, N Rajewsky - PloS one, 2011 - journals.plos.org
Animal miRNAs are a large class of small regulatory RNAs that are known to directly and
negatively regulate the expression of a large fraction of all protein encoding genes. The …

A novel class of microRNA-recognition elements that function only within open reading frames

K Zhang, X Zhang, Z Cai, J Zhou, R Cao… - Nature structural & …, 2018 - nature.com
MicroRNAs (miRNAs) are well known to target 3′ untranslated regions (3′ UTRs) in
mRNAs, thereby silencing gene expression at the post-transcriptional level. Multiple reports …

[HTML][HTML] MicroRNAs: genomics, biogenesis, mechanism, and function

DP Bartel - cell, 2004 - cell.com
MicroRNAs (miRNAs) are endogenous∼ 22 nt RNAs that can play important regulatory
roles in animals and plants by targeting mRNAs for cleavage or translational repression …

The road toward microRNA therapeutics

AG Seto - The international journal of biochemistry & cell biology, 2010 - Elsevier
Within the last 15 years, microRNAs (miRNAs) have emerged as powerful regulators of gene
expression. Highly conserved, these small RNAs appear to regulate nearly every aspect of …