MicroRNAs as prognostic indicators and therapeutic targets: potential effect on breast cancer management

AJ Lowery, N Miller, RE McNeill, MJ Kerin - Clinical Cancer Research, 2008 - AACR
The discovery of microRNAs (miRNA) as novel modulators of gene expression has resulted
in a rapidly expanding repertoire of molecules in this family, as reflected in the concomitant …

Strategies to determine the biological function of microRNAs

J Krützfeldt, MN Poy, M Stoffel - Nature genetics, 2006 - nature.com
MicroRNAs (miRNAs) are regulators of gene expression that control many biological
processes in development, differentiation, growth and metabolism. Their expression levels …

Design and delivery of antisense oligonucleotides to block microRNA function in cultured Drosophila and human cells

MD Horwich, PD Zamore - Nature protocols, 2008 - nature.com
Abstract MicroRNAs (miRNAs),∼ 22-nt RNAs that mediate post-transcriptional regulation of
mRNAs in animals and plants, are a diverse class of regulatory genes whose specific …

Intron-mediated RNA interference and microRNA biogenesis

SY Ying, SL Lin - siRNA and miRNA Gene Silencing: From Bench to …, 2009 - Springer
Nearly 97% of the human genome is non-coding DNA, and introns occupy most of it around
the gene-coding regions. Numerous intronic sequences have been recently found to encode …

MicroRNA‐335‐5p and‐3p synergize to inhibit estrogen receptor alpha expression and promote tamoxifen resistance

EC Martin, AK Conger, TJ Yan, VT Hoang… - FEBS …, 2017 - Wiley Online Library
microRNAs (miRNAs) are small noncoding RNA molecules involved in the regulation of
gene expression and play critical roles in human malignancies. Next‐generation …

Kinetic analysis reveals successive steps leading to miRNA‐mediated silencing in mammalian cells

J Béthune, CG Artus‐Revel, W Filipowicz - EMBO reports, 2012 - embopress.org
MicroRNAs (miRNAs) regulate most cellular functions, acting by posttranscriptionally
repressing numerous eukaryotic mRNAs. They lead to translational repression …

Targeting of mRNAs by multiple miRNAs: the next step

ME Peter - Oncogene, 2010 - nature.com
Micro (mi) RNAs are small noncoding RNAs that regulate expression of the majority of the
genes in the genome at either the messenger RNA (mRNA) level (by degrading mRNA) or …

Characterization of endogenous human Argonautes and their miRNA partners in RNA silencing

A Azuma-Mukai, H Oguri, T Mituyama… - Proceedings of the …, 2008 - National Acad Sciences
Small RNAs triggering RNA silencing are loaded onto Argonautes and then sequence-
specifically guide them to target transcripts. Epitope-tagged human Argonautes (hAgo1 …

The art of microRNA: various strategies leading to gene silencing via an ancient pathway

G Tang, X Tang, V Mendu, X Tang, X Jia… - … et Biophysica Acta (BBA …, 2008 - Elsevier
MicroRNAs (miRNAs), an endogenous type of small RNAs of∼ 22 nucleotides (nt), have
long resided in the cells of plants and animals including humans, constituting an ancient …

Biogenesis and mechanisms of microRNA‐mediated gene regulation

V Rani, RS Sengar - Biotechnology and bioengineering, 2022 - Wiley Online Library
Endogenous RNAs that control posttranscriptional gene expression are microRNAs
(miRNAs). These small regulatory molecules play a crucial role in certain biological …