Neuroblastoma (NB) is a primitive neuroectodermal tumor and the second most common
solid tumor in children. NB exhibits heterogeneous behavior and spontaneous regression …

The transcriptional coactivators YAP and TAZ are downstream targets inhibited by the Hippo
tumor suppressor pathway. The expression level of TAZ is recently shown to be elevated in …

The bromodomain and extraterminal (BET) proteins are epigenetic “readers” of acetylated
histones in chromatin and have been identified as promising therapeutic targets in diverse …

Special AT-rich sequence-binding protein 1 (Satb1) governs genome-wide transcriptional
programs. Using a conditional knockout mouse, we find that Satb1 is required for normal …

TUDOR domain–containing proteins (TDRDs) are chiefly responsible for recognizing methyl-
lysine/arginine residue. However, how TDRD dysregulation contributes to breast …

Posttranslational modifications add tremendous complexity to proteomes; however, gaps
remain in knowledge regarding the function and regulatory mechanism of newly discovered …

Cancer cells rely on dysregulated gene expression. This establishes specific transcriptional
addictions that may be therapeutically exploited. Yet, the mechanisms that are ultimately …

Mitosis is largely driven by posttranslational modifications of proteins. Recent studies
suggest that protein acetylation is prevalent in mitosis, but how protein acetylation …

Nucleotidase Domain Containing 2 (NT5DC2) is a novel oncoprotein, the regulatory effects
of which have not been well characterized. This study aimed to investigate the expression …

Glioblastoma (GBM) is the most lethal type of human brain cancer, where deletions and
mutations in the tumour suppressor gene PTEN (phosphatase and tensin homolog) are …