The purpose of this study was to create craniofacial growth disturbances via synostoses of
sutures of the cranial base, as well as of other various selected sutures of the anterior cranial …

Background: Transforming growth factor (TGF)-β1 has been associated with cranial suture
fusion, whereas TGF-β3 has been associated with suture patency. The mouse posterofrontal …

Background: Craniosynostosis is the premature fusion of cranial sutures early in
development. Mice are commonly used to study the mechanisms driving both normal and …

Objective: Craniosynostosis is a premature fusion of 1 or more cranial sutures. It may occur
with additional morphological abnormalities (syndromic) or in isolation. Studies suggest that …

Cephalic development involves exceedingly complex morphogenetic mechanisms built on
conserved elements that have undergone enor-mous evolutionary change." Precisely …

Craniosynostosis is a congenital disorder of premature ossification of cranial sutures,
occurring in one of approximately every 2500 live human births. This work addressed a …

The biology underlying craniosynostosis remains unknown. Previous studies have shown
that the underlying dura mater, not the suture itself, signals a suture to fuse. The purpose of …

Cranial bones articulate in areas called sutures that must remain patent until skull growth is
complete. Craniosynostosis is the condition that results from premature closure of one or …

The mechanical properties of the adult human skull are well documented, but little
information is available for the infant skull. To determine the age-dependent changes in skull …

Background Facial deformities in syndromic craniosynostosis are not only functionally,
psychosocially, and aesthetically impairing but also notoriously challenging to reconstruct …