Targeted toxins (TT) for cancer treatment are a class of hybrid biologic comprised of a
targeting domain coupled chemically or genetically to a proteinaceous toxin payload. The …

Most molecular target-based therapeutic research facilities use two basic techniques:
protein-kinase inhibitors and monoclonal antibodies. However, they continue to face …

Background: Ribosome-inactivating proteins (RIPs) are wildly found in multiple species of
plants, bacteria and fungi. As a special family of protein toxins, RIPs can inhibit protein …

Ribosome-inactivating proteins (RIPs) are enzymes (3.2. 2.22) that possess N-glycosilase
activity that irreversibly inhibits protein synthesis. RIPs have been found in plants, fungi …

Ribosome inactivating proteins (RIPs) form a class of toxins that was identified over a
century ago. They continue to fascinate scientists and the public due to their very high …

The term ribosome-inactivating protein (RIP) is used to denominate proteins mostly of plant
origin, which have N-glycosidase enzymatic activity leading to a complete destruction of the …

Toxin domains from plants or bacterial origin (such as Diphtheria toxin (DT) or
Pseudomonas exotoxin A (PEA), which are endowed with ADP-ribosylation activity of the …

The concept of “magic bullets”, ie, drugs able to selectively act on target cells, formulated by
Paul Ehrlich more than one century ago, gave rise to the idea of immunotargeting, one of the …

Immunotoxins are chimeric proteins obtained by linking a toxin to either an intact antibody or
an antibody fragment. Conjugation can be obtained by chemical or genetic engineering …

Ribosome-inactivating proteins (RIPs) are EC3. 2.32. 22 N-glycosidases that recognize a
universally conserved stem-loop structure in 23S/25S/28S rRNA, depurinating a single …