Abstract Ribosome-inactivating proteins (RIPs, 1) are plant enzymes that damage ribosomes
in an irreversible manner. They can be divided into type 1 RIPs, which are single-chain …

Immunotoxins are chimeric proteins composed of an antibody domain that specifically
directs the action of the toxic domain, resulting in the death of the targeted cells. Over recent …

Targeted anti-tumor toxins consist of a toxic functional moiety that is chemically linked or
recombinantly fused to a cell-directing ligand. Ribosome-inactivating proteins (RIPs) …

Ribosome inactivating proteins from plants have been widely used for the preparation of
immunotoxins and hormonotoxins, which have potential application in the therapy of …

Plant Ribosome-inactivating proteins (RIPs) including the type I RIP Saporin have been
used for the construction of Immunotoxins (ITxs) obtained via chemical conjugation of the …

The aim of this study was to determine the suitability of a ribosome-inactivating protein (RIP)
from barley endosperm for use as an immunotoxin. This barley RIP is identical with the 30 …

After more than 50 years of research, studies on the structure and biological activities of
ribosome-inactivating proteins (RIPs) continue to provide a field of great interest within the …

Bovine seminal ribonuclease (BSRNase) is an unusual member of the ribonuclease
superfamily, because of its remarkable anti-tumour and immunosuppressive properties. We …

Type 2 ribosome-inactivating protein toxins (RIP-II toxins) were enriched and purified prior to
enzymatic digestion and LC-MS analysis. The enrichment of the RIP-II family of plant …

Ribosome-inactivating proteins (RIPs), mostly from plants, are enzymes which depurinate
rRNA, thus inhibiting protein synthesis. They also depurinate other polynucleotide …