Many, potentially all, inflammatory and immune cells express purinergic receptors of the P1
and P2 type. In recent years, availability of molecular probes and, in some cases, specific …

The purinergic receptor P2X7 is highly expressed in immune peripheral and central cells
suggesting its important role in numerous diseases characterized by inflammatory …

The inflammatory process, orchestrated against a variety of injurious stimuli, is composed of
three inter-related phases; initiation, propagation and resolution. Understanding the …

P2 nucleotide receptors are subdivided into two families: P2X ionotropic ligand‐gated ion
channel receptors and P2Y metabotropic G‐protein‐coupled receptors. Seven subtypes of …

The P2X 7 purinoceptor is unique amongst the P2X receptor family in that its activation is
able to stimulate the release of mature, biologically active interleukin-1β (IL-1β), as well as a …

Purine nucleotides are well established as extracellular signaling molecules. P2X receptors
are ATP‐gated cation channels that mediate fast excitatory transmission in diverse regions …

The P2X7 receptor is involved in several processes relevant to inflammation (cytokine
release, NO generation, killing of intracellular pathogens, cytotoxicity); thus, it may be an …

The P2Y 11 receptor is a G protein-coupled receptor that is stimulated by endogenous
purine nucleotides, particularly ATP. Amongst P2Y receptors it has several unique …

Purinergic receptors, also known as purinoceptors, are ligand gated membrane ion
channels involved in many cellular functions. Among all identified purinergic receptors, P2X …

Macrophages are unique innate immune cells that play an integral role in the defense of the
host by virtue of their ability to recognize, engulf, and kill pathogens while sending out …