DARPP-32 mediates the actions of multiple drugs of abuse
P Svenningsson, AC Nairn, P Greengard - The AAPS journal, 2005 - Springer
Drugs of abuse share the ability to enhance dopaminergic neurotransmission in the dorsal
and ventral striatum. The action of dopamine is modulated by additional neurotransmitters …
and ventral striatum. The action of dopamine is modulated by additional neurotransmitters …
The role of DARPP-32 in the actions of drugs of abuse
The dopamine-and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), plays a key
role in dopaminoceptive neurons in the neostriatum (and likely in other brain regions) in …
role in dopaminoceptive neurons in the neostriatum (and likely in other brain regions) in …
DARPP-32: an integrator of neurotransmission
P Svenningsson, A Nishi, G Fisone… - Annu. Rev …, 2004 - annualreviews.org
Dopamine-and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified
initially as a major target for dopamine and protein kinase A (PKA) in striatum. However …
initially as a major target for dopamine and protein kinase A (PKA) in striatum. However …
[HTML][HTML] DARPP-32: from neurotransmission to cancer
A Belkhiri, S Zhu, W El-Rifai - Oncotarget, 2016 - ncbi.nlm.nih.gov
Dopamine and cAMP-regulated phosphoprotein Mr 32,000 (DARPP-32), also known as
phosphoprotein phosphatase-1 regulatory subunit 1B (PPP1R1B), was initially discovered …
phosphoprotein phosphatase-1 regulatory subunit 1B (PPP1R1B), was initially discovered …
Potential for targeting dopamine/DARPP-32 signaling in neuropsychiatric and neurodegenerative disorders
A Nishi, T Shuto - Expert Opinion on Therapeutic Targets, 2017 - Taylor & Francis
Introduction: Alterations in dopamine neurotransmission has been implicated in
pathophysiology of neuropsychiatric and neurodegenerative disorders, and DARPP-32 …
pathophysiology of neuropsychiatric and neurodegenerative disorders, and DARPP-32 …
[HTML][HTML] Phosphorylation of DARPP-32 at Threonine-34 is required for cocaine action
V Zachariou, V Sgambato-Faure, T Sasaki… - …, 2006 - nature.com
Mice lacking DARPP-32, a striatal-enriched phosphoprotein, show abnormal behavioral and
biochemical responses to cocaine, but the role of individual phosphorylation sites in DARPP …
biochemical responses to cocaine, but the role of individual phosphorylation sites in DARPP …
Drugs of abuse modulate the phosphorylation of ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in the basal ganglia
ARPP-21 is a cyclic AMP-regulated phosphoprotein of Mr 21 kDa that is enriched in the cell
bodies and terminals of medium-sized spiny neurons in the basal ganglia. Using a new …
bodies and terminals of medium-sized spiny neurons in the basal ganglia. Using a new …
Cocaine self-administration in mice is inversely related to phosphorylation at Thr34 (protein kinase A site) and Ser130 (kinase CK1 site) of DARPP-32
Y Zhang, P Svenningsson, R Picetti… - Journal of …, 2006 - Soc Neuroscience
The reinforcing effect of cocaine is associated with increases in dopamine in the striatum.
The phosphoprotein DARPP-32 (dopamine-and cAMP-regulated phosphoprotein) has been …
The phosphoprotein DARPP-32 (dopamine-and cAMP-regulated phosphoprotein) has been …
Cell type–specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs
HS Bateup, P Svenningsson, M Kuroiwa, S Gong… - Nature …, 2008 - nature.com
DARPP-32 is a dual-function protein kinase/phosphatase inhibitor that is involved in striatal
signaling. The phosphorylation of DARPP-32 at threonine 34 is essential for mediating the …
signaling. The phosphorylation of DARPP-32 at threonine 34 is essential for mediating the …
[HTML][HTML] DARPP-32, jack of all trades… master of which?
M Yger, JA Girault - Frontiers in behavioral neuroscience, 2011 - frontiersin.org
DARPP-32 (PPP1R1B) was discovered as a substrate of cAMP-dependent protein kinase
(PKA) enriched in dopamine-innervated brain areas. It is one of three related, PKA-regulated …
(PKA) enriched in dopamine-innervated brain areas. It is one of three related, PKA-regulated …