The production of recombinant proteins in the microbial host Escherichia coli often results in
the formation of cytoplasmic protein inclusion bodies (IBs). Proteins forming IBs are often …

The formation of inclusion bodies (IBs) is considered as an Achilles heel of heterologous
protein expression in bacterial hosts. Wide array of techniques has been developed to …

Recombinant proteins are becoming increasingly important for industrial applications, where
Escherichia coli is the most widely used bacterial host for their production. However, the …

Formation of inclusion bodies in bacterial hosts poses a major challenge for large scale
recovery of bioactive proteins. The process of obtaining bioactive protein from inclusion …

Recombinant protein production has revolutionized healthcare with biopharmaceutical
products dominating the pharmaceutical pipelines today. E. coli remains one of the most …

The formation of inclusion bodies (IBs) during expression of recombinant therapeutic
proteins using E. coli is a significant hurdle in producing high-quality, safe, and efficacious …

Recombinant protein production in bacteria is often accompanied by the formation of
aggregates, known as inclusion bodies (IBs). Although several strategies have been …

The bacterium Escherichia coli is a major host for recombinant protein production of non-
glycosylated products. Depending on the expression strategy, the recombinant protein can …

Protein aggregation is commonly observed phenomenon occurring during production of
recombinant proteins in genetically engineered organisms over-expressing foreign genes …

Recombinant DNA technology enables the production of valuable foreign proteins at high
expression rates and high concentrations. Escherichia coli is one of the most widely used …