Papillary thyroid cancers are the most common thyroid malignancy. They usually carry a
favorable prognosis, although patients with invasive or metastatic tumors that no longer trap …

In recent years, significant progress has been made in elucidating the genetic bases
promoting tumorigenesis in various human neoplasms. Constitutive activation of the mitogen …

Thyroid papillary carcinoma is the most common type of endocrine cancer. It is frequently
associated with genetic alterations leading to activation of the MAPK signaling pathway. The …

Thyroid cancers stand out among solid tumours because many of the tumour-initiating
genetic events have been identified. Mutations leading to constitutive activation of MAP …

Thyroid cancer is the most common malignant tumor of the endocrine system and accounts
for approximately 1% of all newly diagnosed cancer cases. The most frequent type of thyroid …

Carcinomas of the thyroid comprise a heterogeneous group of neoplasms with distinctive
clinical and pathological characteristics. Over the past 15 years, the application of molecular …

Background: Aberrant activation of the phosphatidylinositol-3 kinase (PI3K)/Akt pathway
plays a fundamental role in thyroid tumorigenesis, particularly in follicular thyroid cancer …

Thyroid carcinoma is the most common endocrine malignancy, and although the disease
generally has an excellent prognosis, therapeutic options are limited for patients not cured …

Examines the roles played by the ras, gsp, TSHR, ret, trk and met genes in human epithelial
thyroid spontaneous or radiation-induced tumorigenesis. Activation of Ras family genes; …

Context: Genetic alterations in receptor tyrosine kinases (RTKs) and phosphatidylinositol 3-
kinase (PI3K)/Akt and MAPK pathways have not been fully defined in anaplastic and …