Intracellular signaling pathways that promote axon regeneration are closely linked to the
mechanism of neurite outgrowth. TC10, a signaling molecule that acts on neurite outgrowth …

We have made a rat cDNA library using nerve-transected hypoglossal nuclei. Using this
library, we performed expressed-sequence tag analysis coupled with in situ hybridization to …

Cyclic AMP plays a pivotal role in neurite growth. During outgrowth, a trafficking system
supplies membrane at growth cones. However, the cAMP‐induced signaling leading to the …

Mammalian central nervous system (CNS) neurons lose axon regenerative ability as they
mature. This failure to regenerate shows a clear contrast to a remarkable potential of axon …

Using mouse optic nerve (ON) crush as a CNS injury model, we and others have found that
activation of the mammalian target of rapamycin complex 1 (mTORC1) in mature retinal …

Regeneration in the CNS is blocked by many different growth inhibitory proteins. To foster
regeneration, we have investigated a strategy to block the neuronal response to growth …

Damage to neurons in the central nervous system often leads to a permanent loss of
function due to several factors, including reduced capacity of axons to regenerate and an …

Peripheral nerve injury triggers the activation of RhoA in spinal motor and peripheral
sensory neurons. RhoA activates a number of effector proteins including the Rho-associated …

Ras homolog enriched in brain (Rheb) is a small GTPase that activates mammalian target of
rapamycin complex 1 (mTORC1). Previous studies have shown that constitutively active …

The highly dynamic remodeling and cross talk of the microtubule and actin cytoskeleton
support neuronal morphogenesis. Small RhoGTPases family members have emerged as …