Cytomegalovirus (CMV) resistance in patients with CMV retinitis and AIDS treated with oral or intravenous ganciclovir

WL Drew, MJ Stempien, J Andrews… - The Journal of …, 1999 - academic.oup.com
Abstract Treatment of cytomegalovirus (CMV) retinitis with oral ganciclovir results in
relatively low plasma concentrations of drug, which theoretically could cause more frequent …

Cytomegalovirus retinitis and viral resistance: ganciclovir resistance

DA Jabs, C Enger, JP Dunn, M Forman… - The Journal of …, 1998 - academic.oup.com
Cytomegalovirus (CMV) retinitis is among the most common opportunistic infections in
patients with AIDS and a substantial cause of visual loss. With long-term therapy, resistant …

Change over time in incidence of ganciclovir resistance in patients with cytomegalovirus retinitis

BK Martin, MO Ricks, MS Forman… - Clinical infectious …, 2007 - academic.oup.com
Background. In the mid-1990s, the incidence of cytomegalovirus (CMV) resistance to
ganciclovir was estimated to be∼ 25% by 1 year after diagnosis of retinitis in patients with …

Cytomegalovirus polymerase chain reaction viraemia in patients receiving ganciclovir maintenance therapy for retinitis

FE Bowen, VC Emery, P Wilson, MA Johnson… - Aids, 1998 - journals.lww.com
Objectives: To determine whether recurrence of polymerase chain reaction (PCR) viraemia
during maintenance ganciclovir for cytomegalovirus (CMV) retinitis correlates with (i) CMV …

Foscarnet therapy for ganciclovir-resistant cytomegalovirus retinitis in patients with AIDS

MA Jacobson, WL Drew, J Feinberg… - Journal of Infectious …, 1991 - academic.oup.com
Infections caused by cytomegalovirus (CMV) resistantin vitroto ganciclovir, defined as
requiring> 6 µmol of ganciclovir for ED50 have developed in some AIDS patients with …

Polyradiculopathy associated with ganciclovir-resistant cytomegalovirus in an AIDS patient: phenotypic and genotypic characterization of sequential virus isolates

IL Smith, M Shinkai, WR Freeman… - Journal of Infectious …, 1996 - academic.oup.com
To investigate the role of antiviral drug resistance in cytomegalovirus (CMV) disease
progression, CMV cultured from an AIDS patient who developed progressive CMV disease …

Cytomegalovirus retinitis and viral resistance: prevalence of resistance at diagnosis, 1994

DA Jabs, JP Dunn, C Enger, M Forman… - Archives of …, 1996 - jamanetwork.com
Objective: To determine the prevalence of cytomegalovirus (CMV) isolates resistant to
ganciclovir sodium or foscarnet sodium at the time of diagnosis of CMV retinitis, prior to the …

Emergence of drug-resistant cytomegalovirus retinitis in the contralateral eyes of patients with AIDS treated with ganciclovir

Y Imai, C Shum, DF Martin… - The Journal of …, 2004 - academic.oup.com
The purpose of the present study was to examine the emergence of ganciclovir-resistant
virus in the contralateral eyes of patients who received treatment for cytomegalovirus retinitis …

Cytomegalovirus (CMV) culture results, drug resistance, and clinical outcome in patients with AIDS and CMV retinitis treated with foscarnet or ganciclovir

Studies of Ocular Complications of AIDS … - Journal of Infectious …, 1997 - academic.oup.com
The objectives of the study were to examine the clinical significance of cytomegalovirus
(CMV) culture results and drug susceptibilities in CMV isolates from patients with AIDS …

Longitudinal observations on mutations conferring ganciclovir resistance in patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis: The …

DA Jabs, BK Martin, MS Forman, JP Dunn… - American journal of …, 2001 - Elsevier
PURPOSE: Cytomegalovirus retinitis is the most common intraocular infection in patients
with acquired immunodeficiency syndrome (AIDS). With prolonged suppressive …