We previously identified TNFSF15 as the most significant susceptibility gene at non-HLA loci
for both primary biliary cirrhosis (PBC) and Crohn's diseases (CD) in the Japanese …

We conducted a case-control study to assess the roles of tumor necrosis factor (TNF)-α
polymorphisms, substance use habits, and chronic hepatitis B virus (HBV)/hepatitis C virus …

OBJECTIVES: Susceptibility to autoimmune hepatitis (AIH) has been linked to different HLA-
DR antigens in distinct populations. Recently, an A–G polymorphism in exon 1 of the …

Objectives The development and progression of alcoholic hepatitis are controlled by an
extensive cytokine network which involves pro-inflammatory and anti-inflammatory …

Autoimmune hepatitis (AIH) is a rare chronic progressive liver disease with autoimmune
features. It mainly affects middle-aged women. AIH is occasionally complicated with liver …

Background & Aims Autoimmune hepatitis (AIH) is an uncommon autoimmune liver disease
of unknown etiology. We used a genome-wide approach to identify genetic variants that …

Background Autoimmune hepatitis (AIH) is a relatively rare chronic liver disease of unknown
etiology. The genetic background affects susceptibility, clinical phenotype, and prognosis …

Genome scanning studies suggest an important role for genes outside the major
histocompatibility complex in autoimmunity. Key candidates are those genes involved in …

Background/Aims: Primary sclerosing cholangitis is associated with the HLA haplotypes A1-
B8-DRB3* 0101-DRB1* 0301-DQA1* 0501-DQB1* 0201 and DRB3* 0101-DRB1* 1301 …

Tumor necrosis factor receptor superfamily 2 (TNFR2) plays an important role in controlling
the progression of antiviral and antitumorr. Evidence suggests that TNFR2 is involved in the …