To successfully infect, replicate, and persist in the host, viruses have evolved numerous
strategies to take control of multiple cellular processes, including those that target …

During the co-evolution of viruses and their hosts, the latter have equipped themselves with
an elaborate immune system to defend themselves from the invading viruses. In order to …

During the co-evolution of viruses and their hosts, the latter have equipped themselves with
an elaborate immune system to defend themselves from the invading viruses. In order to …

Protein-protein interactions play a central role in biological processes and thus are an
appealing target for innovative drug design and development. They can be targeted by small …

To successfully replicate and spread, viruses must take control of multiple cellular
processes. Depending on the cell type infected, a virus may drive cellular differentiation …

Multichain immune recognition receptors (MIRRs) represent a family of structurally related
but functionally different surface receptors expressed on different cells of the immune …

Single-chain receptors and multichain immune recognition receptors (SRs and MIRRs,
respectively) represent families of structurally related but functionally different surface …

Signal transduction by cell surface receptors in the context of heterogeneous and variable
cellular environments plays a pivotal role in regulating many biological processes, including …

The inflammatory milieu is the natural habitat for a pathogenic infection, characterised by
activity of pro-inflammatory signalling pathways and inflammatory cytokines. Viral entry …

Highlights•IL-10 signaling is a common target for altering a variety of immune
responses.•High resolution structures reveal how chemokine binding can alter cell signaling …