Mechanisms of lipid homeostasis and its impairment are of crucial importance for
atherogenesis, and their understanding is necessary for successful development of new …

In industrialized societies with excess food supply, obesity is an expanding problem. As a
result of metabolic overload, besides obesity, insulin resistance, type-2 diabetes …

Atherosclerosis is a chronic inflammatory disease and a leading cause of human mortality.
The lesional microenvironment contains a complex accumulation of variably oxidized lipids …

Cholesterol-loaded macrophages are present at all stages of atherogenesis, and recent in
vivo data indicate that these cells play important roles in both early lesion development and …

The influence of the hypercholesterolemia associated with atherosclerosis on monocytes is
poorly understood. Monocytes are exposed to high concentrations of lipids, particularly …

A key aspect of atherosclerosis is the maladaptive inflammatory response to lipoprotein
accumulation in the artery. The failure to decrease lipid accumulation, to clear apoptotic …

Mammalian cells have evolved complex feedback mechanisms to ensure sufficient supply of
cholesterol and to prevent its excessive accumulation. During the process of atherosclerosis …

Low-density lipoprotein (LDL) is a major extracellular carrier of cholesterol and, as such,
plays important physiologic roles in cellular function and regulation of metabolic pathways …

Formation of foam cells is a hallmark at the initial stages of atherosclerosis. Monocytes
attracted by pro‐inflammatory stimuli attach to the inflamed vascular endothelium and …

Atherogenesis requires and is highly influenced by the interaction between lipoproteins and
macrophages. Most of the focus to date has been on the ability of atherogenic lipoproteins …