Role of oxidative stress and reduced endogenous hydrogen sulfide in diabetic nephropathy

A Hussain Lodhi, FD Ahmad, K Furwa… - Drug Design …, 2021 - Taylor & Francis
Purpose Persistent hyperglycemia lead towards depletion of hydrogen sulfide (H2S)
resulting in generation of oxidative stress and diabetic nephropathy. The aim of the current …

H2S donors attenuate diabetic nephropathy in rats: Modulation of oxidant status and polyol pathway

MM Safar, RM Abdelsalam - Pharmacological Reports, 2015 - Springer
Background Sulfurous mineral water and its main active ingredient sodium hydrosulfide
(NaHS) are major sources of H 2 S. The present study aimed to explore their protective effect …

[HTML][HTML] H2S Inhibits Hyperglycemia-Induced Intrarenal Renin-Angiotensin System Activation via Attenuation of Reactive Oxygen Species Generation

H Xue, P Yuan, J Ni, C Li, D Shao, J Liu, Y Shen… - PloS one, 2013 - journals.plos.org
Decrease in endogenous hydrogen sulfide (H2S) was reported to participate in the
pathogenesis of diabetic nephropathy (DN). This study is aimed at exploring the relationship …

[HTML][HTML] Hydrogen sulfide alleviates diabetic nephropathy in a streptozotocin-induced diabetic rat model

X Zhou, Y Feng, Z Zhan, J Chen - Journal of Biological Chemistry, 2014 - ASBMB
Accumulating evidence has demonstrated that hydrogen sulfide (H 2 S) plays critical roles in
the pathogenesis of chronic kidney diseases. This study was designed to investigate …

[HTML][HTML] Combined effect of hydrogen sulphide donor and losartan in experimental diabetic nephropathy in rats

M Kaur, S Sachdeva, O Bedi, T Kaur… - Journal of Diabetes & …, 2015 - Springer
Background Diabetic nephropathy (DN) is one of the complex complications of Diabetes
Mellitus (DM). The present study has been designed to examine protective role of hydrogen …

Hydrogen sulfide treatment promotes glucose uptake by increasing insulin receptor sensitivity and ameliorates kidney lesions in type 2 diabetes

R Xue, DD Hao, JP Sun, WW Li, MM Zhao… - Antioxidants & redox …, 2013 - liebertpub.com
Aims: To examine if hydrogen sulfide (H2S) can promote glucose uptake and provide
amelioration in type 2 diabetes. Results: Treatment with sodium hydrosulfide (NaHS, an H2S …

[HTML][HTML] Hydrogen sulfide: recent progression and perspectives for the treatment of diabetic nephropathy

HJ Sun, ZY Wu, L Cao, MY Zhu, TT Liu, L Guo, Y Lin… - Molecules, 2019 - mdpi.com
Diabetic kidney disease develops in approximately 40% of diabetic patients and is a major
cause of chronic kidney diseases (CKD) and end stage kidney disease (ESKD) worldwide …

H2S improves renal fibrosis in STZ-induced diabetic rats by ameliorating TGF-β1 expression

Y Li, L Li, O Zeng, JM Liu, J Yang - Renal Failure, 2017 - Taylor & Francis
Nephropathy develops in many patients with type 1 diabetes mellitus (T1DM). However, the
specific mechanisms and therapies remain unclear. For this purpose we investigated the …

Hydrogen sulfide in diabetic complications: Focus on molecular mechanisms

L Qian, X Liu, Q Chai, R Wang - Endocrine, Metabolic & …, 2018 - ingentaconnect.com
Background: A growing number of studies have indicated that hydrogen sulfide (H2S) affects
the development of diabetes and its complications, but the specific mechanism is not …

Hydrogen sulfide induces heme oxygenase-1 in human kidney cells

E D'Araio, N Shaw, A Millward, A Demaine… - Acta …, 2014 - Springer
Hydrogen sulfide (H 2 S) has been shown to have a potential protective role in a number of
disease states including diabetes and various kidney disorders; however, the mechanisms …