DNA methylation as a dynamic regulator of development and disease processes: spotlight on the prostate

KP Keil, CM Vezina - Epigenomics, 2015 - Taylor & Francis
Prostate development, benign hyperplasia and cancer involve androgen and growth factor
signaling as well as stromal–epithelial interactions. We review how DNA methylation …

Epigenome-wide tumor DNA methylation profiling identifies novel prognostic biomarkers of metastatic-lethal progression in men diagnosed with clinically localized …

S Zhao, MS Geybels, A Leonardson, R Rubicz… - Clinical Cancer …, 2017 - AACR
Abstract Purpose: Aside from Gleason sum, few factors accurately identify the subset of
prostate cancer patients at high risk for metastatic progression. We hypothesized that …

Oxidative stress and DNA methylation in prostate cancer

KV Donkena, CYF Young… - Obstetrics and gynecology …, 2010 - Wiley Online Library
The protective effects of fruits, vegetables, and other foods on prostate cancer may be due to
their antioxidant properties. An imbalance in the oxidative stress/antioxidant status is …

Prognostic DNA methylation markers for prostate cancer

SH Strand, TF Orntoft, KD Sorensen - International journal of molecular …, 2014 - mdpi.com
Prostate cancer (PC) is the most commonly diagnosed neoplasm and the third most
common cause of cancer-related death amongst men in the Western world. PC is a clinically …

Epigenetic targets in the diagnosis and treatment of prostate cancer

M Manoharan, K Ramachandran, MS Soloway… - International braz j …, 2007 - SciELO Brasil
Prostate cancer (PC) is one of leading cause of cancer related deaths in men. Various
aspects of cancer epigenetics are rapidly evolving and the role of 2 major epigenetic …

Comprehensive methylome sequencing reveals prognostic epigenetic biomarkers for prostate cancer mortality

R Pidsley, D Lam, W Qu, TJ Peters… - Clinical and …, 2022 - Wiley Online Library
Background Prostate cancer is a clinically heterogeneous disease with a subset of patients
rapidly progressing to lethal‐metastatic prostate cancer. Current clinicopathological …

Methylated genes as potential biomarkers in prostate cancer

V Phé, O Cussenot, M Rouprêt - BJU international, 2010 - Wiley Online Library
Prostate cancer is the most common malignancy of the urogenital tract. Although
controversial, prostate‐specific antigen (PSA) testing is widely used for screening and follow …

Identification of differentially methylated genes in normal prostate tissues from African American and Caucasian men

B Kwabi-Addo, S Wang, W Chung, J Jelinek… - Clinical cancer …, 2010 - AACR
Purpose: Aberrant DNA methylation changes are common somatic alterations in prostate
carcinogenesis. We examined the methylation status of six genes in prostate tissue …

A methyl‐deficient diet modifies histone methylation and alters Igf2 and H19 repression in the prostate

JR Dobosy, VX Fu, JA Desotelle, R Srinivasan… - The …, 2008 - Wiley Online Library
Background Folate and methyl‐group deficiency has been linked to prostate cancer
susceptibility, yet the mechanisms underlying these observations are incompletely …

Genome-wide differentially methylated genes in prostate cancer tissues from African-American and Caucasian men

JM Devaney, S Wang, P Furbert-Harris, V Apprey… - Epigenetics, 2015 - Taylor & Francis
Increasing evidence suggests that aberrant DNA methylation changes may contribute to
prostate cancer (PCa) ethnic disparity. To comprehensively identify DNA methylation …