From the demonstration of the existence of multiple opioid receptors and the isolation of the
endogenous opioid peptides in the brain, it is now clear that the activities of these receptors …

Opioid receptors belong to the family of G-protein-coupled receptors characterized by their
seven transmembrane domains. The activation of these receptors by agonists such as …

The endogenous opioid peptides have multiple physiological actions at both a central and
peripheral level which are mediated by 3 main classes of opioid receptors, μ, δ and κ. The …

A cDNA was isolated from rat brain by low stringency hybridization with the rat μ opioid
receptor cDNA. Sequence analysis of this clone indicated that it contains an open reading …

The cloning and expression of DNA for the three major opioid receptor types (μ, δ, and χ)
present new research opportunities for the characterization of opioid drugs and their …

By screening a rat brain cDNA library using a cloned mu opioid receptor cDNA as probe, a
clone was identified that is very similar to both the mu and delta opioid receptor sequences …

The cloning of the opioid receptors allows the investigation of receptor domains involved in
the peptidic and nonpeptidic ligand interaction and activation of the opioid receptors …

A historical review of the early phases of molecular investigations of opioid receptors is
presented. The 'modern'era of molecular studies of neurotransmitter and drug receptor …

Opioid drugs such as heroin interact directly with opioid receptors whilst other addictive
drugs, including marijuana, alcohol and nicotine indirectly activate endogenous opioid …

O PIOID receptors in the membranes of nerve cells are key elements in a regulatory system
which allows opioids outside the cell to modify intracellular events and alter cell function …