Hereditary spastic paraplegias (HSP) are a group of clinically and genetically
heterogeneous disorders with the hallmark of progressive spastic gait disturbance. We used …

The aim of this study was to identify potential diagnostic markers of Hereditary Spastic
Paraplegia (HSP). We investigated the white matter features of spastic gait (SPG) 11-and …

Mutations in the SPG4 gene (SPG4-HSP) are the most frequent cause of hereditary spastic
paraplegia, but the extent of the neurodegeneration related to the disease is not yet known …

Background SPG11-linked hereditary spastic paraplegia is characterized by multisystem
neurodegeneration leading to a complex clinical and yet incurable phenotype of progressive …

Objective The study aimed to investigate the functional alterations of spontaneous brain
activity in patients with spastic paraplegia type 4 (SPG4), and the relationship with the …

To determine the cortical mechanism that underlies the cognitive impairment and motor
disability in hereditary spastic paraplegia (HSP), nine HSP patients from a Chinese family …

SPG11 mutations are the major cause of autosomal recessive Hereditary Spastic
Paraplegia. The disease has a wide phenotypic variability indicating many regions of the …

BACKGROUND: Hereditary spastic paraplegia is a clinically and genetically heterogeneous
neurodegenerative disorder characterized by progressive spasticity of the lower limbs …

Hereditary spastic paraplegias (HSP) are a group of genetically and clinically
heterogeneous neurologic disorders. Hereby we describe a relatively large group of patients …

Objective: SPG4 is an autosomal dominant pure form of hereditary spastic paraplegia (HSP)
caused by mutations in the SPAST gene. HSP is considered an upper motor neuron …