An initiation/promotion bioassay for chemical carcinogens and tumor promoters has been
developed in rat liver using presumed preneoplastic lesions, foci of gamma …

A short-term initiation/promotion bioassay has been developed in rat liver using putative
preneoplastic foci as the endpoint for the detection of chemical carcinogens. The two …

We have investigated a short-term initiation/promotion assay in rat liver for chemical
carcinogens. Diethylnitrosamine was used as the initiator and phenobarbital and partial …

A single ip injection of diethylnitrosamine (DEN) or benzo [a] pyrene (BAP) in 1-day-old
female rats produced a high incidence of γ-glutamyltranspeptidase-(GGT)-positive …

A number of model systems have been developed to study the initiating and promoting
phases of neoplastic development in rat liver. Four of these protocols use diethylnitrosamine …

The dose—response of phenobarbitat (PB) promotion of hepatocarcinogenesis in rats was
investigated. Male F344 rats were given 1, 4, 16, 75, 300 or 1200 ppm PB solutions given ad …

The dose dependence of the hepatopromoting effects of phenobarbital (PB) was
investigated in a rat liver medium-term bioassay (Ito test) to elucidate a practical threshold …

The incidence of gamma-glutamyltranspeptidase (GGT)-positive foci induced by 0.3
mmol/kg diethylnitrosamine (DENA) followed by promotion with 500 ppm sodium …

The ability of hexachlorobenzene and lindane in diethylnitrosamine (DENA) pretreated rats
to enhance the incidence of gamma-glutamyltrans-peptidase (GGTase)-positive foci was …

An improved transplantation system for the study of carcinogen-altered hepatocytes is
described. This system, which is based on that reported by Laishes and Farber (Cancer …