In order to investigate whether different 'promoters' have the same qualitative and/or
quantitative effects on rat hepatocarcinogenesis, 0.05% of phenobarbital (PB), 0.05% of …

Carcinogenesis was initiated in female rat liver by a single dose of N-nitrosomorpholine;
subsequently phenobarbital (PB) was administered via the diet at a daily dose of 50 mg/kg …

Epidemiological evidence suggests that the human population is exposed to environmental
agents that increase the risk of cancer. The two-stage or initiation-promotion model of …

The effect of di (2-ethylhexyl) phthalate (DEHP), a widely used plasticizer and environmental
contaminant, on the emergence of gamma-glutamyltranspeptidase positive (GGT+) …

The promoting activities of phenobarbital(PB) on the development of ƒÁ-glutamyl
transpeptidase-positive(ƒÁ-GT• ôUH• ô+• ôUS• ô) foci in rat liver with three different initiating …

In this study we demonstrate that chloroform, a widely used industrial solvent, a medicinal
chemical and a common drinking water contaminant, reduces the number of detectable …

Karyotypic analysis of the stages of rat hepatocarcinogenesis has been facilitated by the
development of an initiation-promotion-progression (IPP) protocol that permits separation …

Earlier, we demonstrated that feeding to rats a diet devoid of choline, a lipotropic factor,
markedly enhances hepatoma induction by several chemical carcinogens, and that the diet …

Four pesticides were examined for hepatopromoting activity using a medium‐term bioassay
based upon induction of glutathione S‐transferase placental form (GST‐P) positive foci in …

The effect of concurrent administration of phenobarbital on the hepatocarcinogenicity of N-
nitrosodiethylamine (diethylnitrosamine; DENA) in rats was investigated by determination of …