Enhancing effect of barbital on N-2-fluorenylacetamide-induced rat liver lesions.
H Mori, T Tanaka, A Nishikawa, M Takahashi… - Gan, 1981 - europepmc.org
The enhancing effect of phenobarbital (PB) and barbital on hepatotumorigenesis were
compared by quantitative analysis of the behavior of altered foci following discontinuation of …
compared by quantitative analysis of the behavior of altered foci following discontinuation of …
A comparative study of the efficacy of four barbiturates as promoters of the development of γ-glutamyltranspeptidase-positive foci in the liver of carcinogen treated rats
H Shinozuka, B Lombardi, SE Abanobi - Carcinogenesis, 1982 - academic.oup.com
The promoting action of four barbiturates, and their modulation of the promoting action of a
choline-devoide (CD) diet was investigated by quantitating the γ-glutamyitranspeptidase …
choline-devoide (CD) diet was investigated by quantitating the γ-glutamyitranspeptidase …
Induction of foci of altered, γ-glutamyltranspeptidase-positive hepatocytes in carcinogen-treated rats fed a choline-deficient diet
MA Sells, SL Katyal, S Sell, H Shinozuka… - British Journal of …, 1979 - nature.com
A series of experiments was performed to investigate whether, after exposure of rats to a
chemical hepatocarcinogen, feeding a choline-deficient (CD) diet would promote the …
chemical hepatocarcinogen, feeding a choline-deficient (CD) diet would promote the …
Selective induction of DNA synthesis in mouse preneoplastic and neoplastic hepatic lesions after exposure to phenobarbital.
JE Klaunig - Environmental health perspectives, 1993 - ehp.niehs.nih.gov
Recent evidence has suggested that the induction of DNA synthesis by nongenotoxic
chemical carcinogens plays an important role in the formation of cancer. The present study …
chemical carcinogens plays an important role in the formation of cancer. The present study …
Rat liver foci and in vitro assays to detect initiating and promoting effects of chlorinated ethanes and ethylenes.
HA Milman, DL Story, ES Riccio, A Sivak… - Annals of the New …, 1988 - europepmc.org
Nine chlorinated aliphatics (CAs) were examined in a rat liver foci assay for tumor initiating
and promoting activities. In this model, young adult male Osborne Mendel rats were first …
and promoting activities. In this model, young adult male Osborne Mendel rats were first …
Dose-dependent promoting activity of chloroform in rat liver foci bioassay
E Deml, D Oesterle - Cancer letters, 1985 - Elsevier
Chloroform enhances dose-dependently the number of preneoplastic foci in livers of
weanling female Sprague—Dawley rats. The preneoplastic foci were induced with a single …
weanling female Sprague—Dawley rats. The preneoplastic foci were induced with a single …
Inhibitory effects of phenolic compounds on development of naturally occurring preneoplastic hepatocytic foci in long‐term feeding studies using male F344 rats
A Hagiwara, Y Kokubo, Y Takesada… - Teratogenesis …, 1996 - Wiley Online Library
Five phenolic compounds, namely caffeic acid, sesamol, hydroquinone, catechol, and 4‐
methoxyphenol, were fed to groups of 30 male F344 rats at dietary levels of 2, 2, 0.8, 0.8 …
methoxyphenol, were fed to groups of 30 male F344 rats at dietary levels of 2, 2, 0.8, 0.8 …
Inability of mitogen-induced liver hyperplasia to support the induction of enzyme-altered islands induced by liver carcinogens
A Columbano, GM Ledda-Columbano, G Lee… - Cancer research, 1987 - AACR
Experiments were designed to determine whether liver cell proliferation induced by direct
mitogens is as effective as compensatory cell proliferation consequent to previous cell loss …
mitogens is as effective as compensatory cell proliferation consequent to previous cell loss …
Enzymatic alterations in mouse hepatic nodules induced by a chlorinated hydrocarbon pesticide
EM Essigmann, PM Newberne - Cancer Research, 1981 - AACR
Abstract Male C57BL/6× C3H/anf F1 mice were either untreated or fed 3, 5-dichloro (N-1, 1-
dimethyl-2-propynyl) benzamide, a chlorinated hydrocarbon pesticide, for 12, 18 or 24 …
dimethyl-2-propynyl) benzamide, a chlorinated hydrocarbon pesticide, for 12, 18 or 24 …
Distinction between liver neoplasm promoting and syncarcinogenic effects demonstrated by exposure to phenobarbital or diethylnitrosamine either before or after N-2 …
GM Williams, K Furuya - Carcinogenesis, 1984 - academic.oup.com
The effect on the liver carcinogenicity in rats of sequential administration of either
phenobarbital (PB) or diethylnitros-amine (DEN) given either before or after N-2 …
phenobarbital (PB) or diethylnitros-amine (DEN) given either before or after N-2 …