Conflict of interest: No conflict of interest has been declared. Nonstandard abbreviations
used: free cholesterol (FC); acylcoenzyme A: cholesterol acyltransferase (ACAT); cholesteryl …

Nonstandard abbreviations used: glycophosphatidylinositolanchored (GPI-anchored);
endothelial nitric oxide synthase (eNOS); β-secretase (BACE); endoplasmic reticulum (ER); …

A major characteristic of advanced atherosclerotic lesions is the necrotic, or lipid, core,
which likely plays an important role in the clinical progression of these lesions. Recent data …

In a previous study using the J774 macrophage foam cells, we quantitated the accumulation
of unesterified (free) cholesterol derived from cholesteryl ester hydrolysis in lysosomes, after …

The present study examined free cholesterol (FC) crystallization in macrophage foam cells.
Model foam cells (J774 or mouse peritoneal macrophages [MPMs]) were incubated with …

Atherosclerotic plaques are filled with scavenger cells that have ingested large amounts of
cholesterol and have become so stuffed with cholesteryl ester that they are converted into …

Macrophages in atherosclerotic lesions accumulate free cholesterol (FC) as well as
cholesteryl ester and appear to have high rates of phospholipid (PL) synthesis and …

Lecithin-cholesterol acyltransferase (EC 2.3. 1.43, LCAT) is the enzyme responsible for the
formation of the bulk of cholesteryl ester in human plasma. The LCAT-reaction takes place …

Cholesterol-loaded macrophages are present at all stages of atherogenesis, and recent in
vivo data indicate that these cells play important roles in both early lesion development and …

This study was designed to identify cellular responses associated with free cholesterol (FC)
accumulation in model macrophage foam cells. Mouse peritoneal macrophages (MPMs) or …