The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been
and continue to be a major scientific undertaking-heparin and its derivative remain important …

Publisher Summary This chapter discusses the structural aspects and structure–activity
relationships of heparin/heparan sulfate (HS). The molecular mechanism behind the …

A number of physiological effects have been ascribed to heparin since its discovery almost
80 years ago, many of which are independent from its first-described and best-characterized …

Heparin and heparan sulfate have been shown to interact with a large number of
biologically important proteins regulating important physiological processes. Specific …

Heparin, a sulfated polysaccharide, is a major clinical anticoagulant. It is exploited to
overcome the natural propensity for blood to clot. Surgical procedures often require …

Heparin is a polydisperse, highly sulfated polysaccharide which has been in widespread
clinical use over the past half century. This chapter describes our current understanding of …

The glycosaminoglycan heparan sulfate (HS), is expressed on the surface of virtually all
mammalian cells and is implicated in many crucial biological activities. The activities of HS …

This book describes the complex structures of heparins and heparan sulfates (heparinoids)
and how they are generated by their biosynthetic pathways. The book also details the …

Issues of nomenclature are rarely inspiring; the main emphasis of this presentation will in
fact be on the biosynthesis rather than on the designation of" heparin-like polysaccharides" …

Heparin is the first glycosaminoglycan ever identified. All the heparin-like
glycosaminoglycans that are also isolated from animal tissues or any polysaccharides that …