Nitric oxide (NO) production is critical for the host defense against intracellular pathogens;
however, it is unclear whether NO-dependent control of intracellular organisms depends on …

The production of nitric oxide (NO) by the inducible NO synthase (iNOS) is a key defense
mechanism against intracellular pathogens such as Leishmania. Numerous studies have …

Nitric oxide (NO) is an important antimicrobial effector but also prevents unnecessary tissue
damage by shutting down the recruitment of monocyte-derived phagocytes. Intracellular …

Cutaneous leishmaniasis affects millions of people around the world. Several species of
Leishmania infect mouse strains, and murine models closely reproduce the cutaneous …

Type 2 nitric oxide synthase (NOS2) is required for the Th1-dependent healing of infections
with intracellular microbes, including Leishmania major. Here, we demonstrate the …

Nitric oxide (NO) synthase (iNOS) is required for the resolution of acute cutaneous
leishmaniasis in resistant C57BL/6 mice. As is the case in several other infections, the …

To discover how nitric oxide (NO) synthesis is controlled in different tissues as cells within
these tissues combat intracellular pathogens, we examined three distinctively different …

This study investigated whether Leishmania species, the etiologic agent of cutaneous
(Leishmania major) and visceral (Leishmania donovani) leishmaniasis, could differentially …

Active human visceral leishmaniasis (VL) is characterized by a progressive increase in
visceral parasite burden, cachexia, massive splenomegaly, and hypergammaglobulinemia …

Induction of inducible nitric oxide synthase in mononuclear phagocytes by IFN-γ and innate
tumor necrosis factor (TNF) provide the basis for an effective immune response to the …