Induction of inducible nitric oxide synthase in mononuclear phagocytes by IFN-γ and innate
tumor necrosis factor (TNF) provide the basis for an effective immune response to the …

Leishmania braziliensis are intracellular parasites that cause unique clinical forms of
cutaneous leishmaniasis. Previous studies with other leishmania species demonstrated that …

In the Leishmania major mouse model of cutaneous leishmaniasis inducible nitric oxide
synthase (iNOS) is crucial for the killing of the parasite in the skin and draining lymph node …

Nitric oxide (NO) is an anti-microbial effector of the innate immune system which plays major
role in non-specific killing of various pathogens including protozoan parasites. However …

Previous studies have shown that nitric oxide (NO) production is a major effector mechanism
in the control of Leishmania major infection in the BALB/c and C3H murine models. The …

Type 2 nitric oxide synthase (iNOS or NOS2) was originally described as an enzyme that is
expressed in activated macrophages, generates nitric oxide (NO) from the amino acid L …

In Leishmania‐infected macrophages (MΦ), the formation of reactive nitrogen intermediates
by the inducible isoform of nitric oxide synthase (iNOS) is critical for the killing of the …

Parasites of the Leishmania genus are the causative agents of leishmaniasis in humans, a
disease that affects more than 12 million people worldwide. These parasites replicate …

Nitric oxide (NO) is cytotoxic and cytostatic to blood stage malaria parasites in vitro, but the
precise mechanism (s) by which it mediates an effect in vivo is not known. In particular …

Reactive oxygen species (ROS) produced by NADPH phagocyte oxidase isoform (NOX2)
are critical for the elimination of intracellular pathogens in many infections. Despite their …