The immune system can control infectious diseases through different modes of action,
including direct killing or spatial confinement. Addressing how the immune system impacts …

Leishmania are a resilient group of intracellular parasites that infect macrophages. The
resultant complex of diseases, or leishmaniases, caused by the parasites affect over twelve …

Nitric oxide (NO) derived from L–arginine by the catalytic action of inducible NO synthase
(iNOS) plays an important role in killing parasites. Many cell types express high levels of …

In most natural infections or after recovery, small numbers of Leishmania parasites remain
indefinitely in the host. Persistent parasites play a vital role in protective immunity against …

Cutaneous leishmaniasis is caused by protozoan parasites of the genus Leishmania. The
mechanisms of pathogen control have been established primarily in the mouse model of …

Leishmania donovani is a protozoan parasite that causes visceral leishmaniasis, provoking
liver and spleen tissue destruction that is lethal unless treated. The parasite replicates in …

Background Nitric oxide (NO) produced in macrophages plays a pivotal role as a
leishmanicidal agent. A previous study has demonstrated that 20% of the L.(V.) braziliensis …

Ulcer development in patients with cutaneous leishmaniasis (CL) caused by Leishmania
braziliensis is associated with high levels of tumor necrosis factor (TNF). We found that early …

The protozoan Leishmania mexicana parasite causes chronic non-healing cutaneous
lesions in humans and mice with poor parasite control. The mechanisms preventing the …

Background Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease caused by
protozoa of the genus Leishmania. In Morocco, CL is a public health problem mainly caused …