Chronic tegumentary leishmaniasis is characterized by a scarcity of parasites in lesions and
a heightened inflammatory response. Deregulated and hyperactive inflammation contributes …

Leishmania major parasites reside and multiply in late endosomal compartments of host
phagocytic cells. Immune control of Leishmania growth absolutely requires expression of …

The role of nitric oxide (NO) in the anti-leishmanial activity has been confirmed both in vitro
and in vivo. Recently, we demonstrated that NO-mediated apoptosis-like amastigote death …

Murine macrophages can be activated to produce nitric oxide (NO) and superoxide and
these two radicals can react to form peroxynitrite, a powerful oxidant which may be involved …

Highlights•The GP63 metalloprotease selectively degrades molecules involved in
membrane trafficking and nuclear physiology.•Cleavage of VAMP8 and Syt XI disrupts cross …

Nitric oxide (NO) has been demonstrated to be a principal effector molecule responsible for
mediating intracellular killing of Leishmania parasites, the causative organism of …

In experimental visceral leishmaniasis, in which the tissue macrophage is the target, in vivo
responsiveness to conventional chemotherapy (pentavalent antimony [Sb]) requires a T-cell …

We examined the local and systemic production of nitric oxide (NO) and the pattern of
cytokine during the course of Leishmania mexicana infection in susceptible BALB/c and …

We investigated the role of neutrophil elastase (NE) in interactions between murine
inflammatory neutrophils and macrophages infected with the parasite Leishmania major. A …

The antimicrobial effect of activated macrophages on parasites involves nitric oxide (NO).
NO induces intracellular parasite killing in murine leishmaniasis. Nevertheless, the …