Cardiovascular diseases are the leading cause of mortality worldwide. It is widely known
that non-resolving inflammation results in atherosclerotic conditions, which are responsible …

Ischemic heart disease is a common condition and a leading cause of mortality and
morbidity. Macrophages, besides their role in host defense and tissue homeostasis, are …

Emerging evidence points to the involvement of specialized cells of the immune system as
key drivers in the pathophysiology of cardiovascular diseases. Monocytes are an essential …

Cardiac macrophages are abundant in the healthy heart and after myocardial infarction (MI).
Different macrophage phenotypes likely promote myocardial health vs. disease. Infarct …

Cardiovascular disease (CVD) has long been the leading cause of death worldwide, and
myocardial infarction (MI) accounts for the greatest proportion of CVD. Recent research has …

Cardiovascular diseases, such as myocardial infarction (MI), are a leading cause of death
worldwide. Acute MI (AMI) inflicts massive injury to the coronary microcirculation, causing …

The heart contains a population of resident macrophages that markedly expands following
injury through recruitment of monocytes and through proliferation of macrophages. In …

Although great advances have been made, the problem of irreversible myocardium loss due
to the limited regeneration capacity of cardiomyocytes has not been fully solved. The …

Macrophages play critical roles in homeostatic maintenance of the myocardium under
normal conditions and in tissue repair after injury. In the steady-state heart, resident cardiac …

Macrophages are essential components of the immune system and play a role in the normal
functioning of the cardiovascular system. Depending on their origin and phenotype, cardiac …