Despite improvements in the therapy of underlying heart disease, sudden cardiac death is a
major cause of death worldwide. Disturbed Na and Ca handling is known to be a major …

Late sodium current in cardiac cells is very small compared with the fast component, but as it
flows throughout the action potential it may make a substantial contribution to sodium …

The link between calcium (Ca2+) and arrhythmias goes back to the early days of
electrophysiology and calcium measurements. This viewpoint highlights some of the new …

In February 2014, a group of scientists convened as part of the University of California Davis
Cardiovascular Symposium to bring together experimental and mathematical modelling …

Despite recent advances in preventing sudden cardiac death (SCD) due to cardiac
arrhythmia, its incidence in the population at large has remained unacceptably high. Better …

Calcium ions (Ca2+) play a major role in the cardiac excitation-contraction coupling.
Intracellular Ca2+ concentration increases during systole and falls in diastole thereby …

Abnormal calcium (Ca) handling can contribute to arrhythmogenesis directly by triggering
abnormal depolarizations and indirectly by modulating action potential time course and …

Congestive heart failure (HF) is characterized by contractile dysfunction and a high
incidence of sudden death from nonreentrant ventricular arrhythmias, both of which involve …

Acute ischemia results in deadly cardiac arrhythmias that are a major contributor to sudden
cardiac death (SCD). The electrophysiological changes involved have been extensively …

In adapting to disease and loss of tissue, the heart shows great phenotypic plasticity that
involves changes to its structure, composition and electrophysiology. Together with parallel …