Transcriptional profiling in experimental visceral leishmaniasis reveals a broad splenic inflammatory environment that conditions macrophages toward a disease …
F Kong, OA Saldarriaga, H Spratt, EY Osorio… - PLoS …, 2017 - journals.plos.org
Visceral Leishmaniasis (VL), caused by the intracellular protozoan Leishmania donovani, is
characterized by relentlessly increasing visceral parasite replication, cachexia, massive …
characterized by relentlessly increasing visceral parasite replication, cachexia, massive …
Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes
CM Espitia, OA Saldarriaga, BL Travi, EY Osorio… - BMC immunology, 2014 - Springer
Abstract Background The Syrian golden hamster (Mesocricetus aureus) has been used as a
model to study infections caused by a number of human pathogens. Studies of …
model to study infections caused by a number of human pathogens. Studies of …
Splenic CD4+ T Cells in Progressive Visceral Leishmaniasis Show a Mixed Effector-Regulatory Phenotype and Impair Macrophage Effector Function through …
AA Medina-Colorado, EY Osorio, OA Saldarriaga… - PloS one, 2017 - journals.plos.org
Visceral leishmaniasis (VL), caused by infection with the intracellular protozoan Leishmania
donovani, is a chronic progressive disease with a relentlessly increasing parasite burden in …
donovani, is a chronic progressive disease with a relentlessly increasing parasite burden in …
Progressive visceral leishmaniasis is driven by dominant parasite-induced STAT6 activation and STAT6-dependent host arginase 1 expression
EY Osorio, W Zhao, C Espitia, O Saldarriaga… - PLoS …, 2012 - journals.plos.org
The clinicopathological features of the hamster model of visceral leishmaniasis (VL) closely
mimic active human disease. Studies in humans and hamsters indicate that the inability to …
mimic active human disease. Studies in humans and hamsters indicate that the inability to …
The immunopathology of experimental visceral leishmaniasis
PM Kaye, M Svensson, M Ato, A Maroof… - Immunological …, 2004 - Wiley Online Library
Experimental murine infection with the parasites that cause human visceral leishmaniasis
(VL) results in the establishment of infection in the liver, spleen, and bone marrow. In most …
(VL) results in the establishment of infection in the liver, spleen, and bone marrow. In most …
Compartmentalized immune response in leishmaniasis: changing patterns throughout the disease
A Rodríguez-Cortés, E Carrillo, S Martorell, F Todolí… - PLoS …, 2016 - journals.plos.org
Visceral leishmaniasis (VL) is characterized by loss of T-cell responsiveness and absence of
Leishmania-specific IFN-γ production by peripheral blood mononuclear cells. However, the …
Leishmania-specific IFN-γ production by peripheral blood mononuclear cells. However, the …
Transcriptional profiling of macrophages reveals distinct parasite stage-driven signatures during early infection by Leishmania donovani
Macrophages undergo swift changes in mRNA abundance upon pathogen invasion. Herein
we describe early remodelling of the macrophage transcriptome during infection by …
we describe early remodelling of the macrophage transcriptome during infection by …
Simultaneous transcriptional profiling of Leishmania major and its murine macrophage host cell reveals insights into host-pathogen interactions
LAL Dillon, R Suresh, K Okrah, H Corrada Bravo… - BMC genomics, 2015 - Springer
Background Parasites of the genus Leishmania are the causative agents of leishmaniasis, a
group of diseases that range in manifestations from skin lesions to fatal visceral disease …
group of diseases that range in manifestations from skin lesions to fatal visceral disease …
Translational profiling of macrophages infected with Leishmania donovani identifies mTOR- and eIF4A-sensitive immune-related transcripts
V Chaparro, LP Leroux, L Masvidal, J Lorent… - PLoS …, 2020 - journals.plos.org
The protozoan parasite Leishmania donovani (L. donovani) causes visceral leishmaniasis, a
chronic infection which is fatal when untreated. Herein, we investigated whether in addition …
chronic infection which is fatal when untreated. Herein, we investigated whether in addition …
Tissue specific dual RNA-seq defines host–parasite interplay in murine visceral leishmaniasis caused by leishmania donovani and leishmania infantum
S Forrester, A Goundry, BT Dias… - Microbiology …, 2022 - Am Soc Microbiol
Visceral leishmaniasis is associated with hepato-splenomegaly and altered immune and
hematological parameters in both preclinical animal models and humans. We studied …
hematological parameters in both preclinical animal models and humans. We studied …