The lymphatic network that transports interstitial fluid and antigens to lymph nodes
constitutes a conduit system that can be hijacked by invading pathogens to achieve systemic …

Secondary lymphoid tissues are the sites of both innate and adaptive host defense. Aside
from the relatively static nonhematopoietic stromal elements and some macrophages and …

ABSTRACT A hallmark of the mammalian immune system is its ability to respond efficiently
to foreign antigens without eliciting an inappropriate response to self-antigens. Furthermore …

The immune system is a multicentered organ that is characterized by intimate interactions
between its cellular components to efficiently ward off invading pathogens. A key constituent …

Lymph nodes (LNs) contain innate-like lymphocytes that survey the subcapsular sinus
(SCS) and associated macrophages for pathogen entry. The factors promoting this …

Lymph nodes are secondary lymphoid organs in which immune responses of the adaptive
immune system are initiated and regulated. Distributed throughout the body and embedded …

Microanatomical organization of innate immune cells within lymph nodes (LNs) is critical for
the generation of adaptive responses. In particular, steady-state LN-resident dendritic cells …

Allergic immunity is orchestrated by group 2 innate lymphoid cells (ILC2s) and type 2 helper
T (Th2) cells prominently arrayed at epithelial-and microbial-rich barriers. However, ILC2s …

Innate lymphoid cell (ILCs) subsets differentially populate various barrier and non-barrier
tissues, where they play important roles in tissue homeostasis and tissue-specific responses …

The slow interstitial flow that drains fluid from the blood capillaries into the lymphatic
capillaries provides transport of macromolecular nutrients to cells in the interstitium. We …