We determined the size and shape of full-length avian sarcoma virus (ASV) integrase (IN)
monomers and dimers in solution using small angle x-ray scattering. The low resolution data …

The human immunodeficiency virus type 1 (HIV-1) integrase protein (IN) is essential for
integration of the viral DNA into host cell chromosomes. Since IN is expressed and …

A large number of human immunodeficiency virus 1 (HIV-1) integrase (IN) alterations,
referred to as class II substitutions, exhibit pleiotropic effects during virus replication …

The stable insertion of the retroviral genome into the host chromosomes requires the
association between integration complexes and cellular chromatin via the interaction …

Human transcriptional coactivator p75/lens epithelium-derived growth factor (LEDGF) binds
human immunodeficiency virus type 1 (HIV-1) integrase (IN). We studied the effects of …

We have applied small angle x-ray scattering and protein cross-linking coupled with mass
spectrometry to determine the architectures of full-length HIV integrase (IN) dimers in …

tert-Butoxy-(4-phenyl-quinolin-3-yl)-acetic acids (tBPQA) are a new class of HIV-1 integrase
(IN) inhibitors that are structurally distinct from IN strand transfer inhibitors but analogous to …

The catalytic core domain (CCD) of human immunodeficiency virus type 1 (HIV-1) integrase
(IN) harbors the enzyme active site and binds viral and chromosomal DNA during …

Integration of viral DNA into cellular DNA is an essential step in the replication cycle of HIV
and other retroviruses. The first antiviral drugs that target integrase, the viral enzyme that …

ABSTRACT HIV-1 integrase (IN) is the key enzyme catalyzing the proviral DNA integration
step. Although the enzyme catalyzes the integration step accurately in vitro, whether IN is …