Drug-protein binding plays a key role in determining the pharmacokinetics of a drug. The
distribution and protein binding ability of a drug changes over a lifetime, and are important …

Transport proteins play an important role in the adsorption, distribution and elimination of a
wide variety of drugs. Therefore, it is not surprising that transporter-based drug interactions …

Recently, increased interest in drug transporters and research in this area has revealed that
drug transporters play an important role in modulating drug absorption, distribution, and …

All cells necessarily contain tens, if not hundreds, of carriers for nutrients and intermediary
metabolites, and the human genome codes for more than 1000 carriers of various kinds …

Permeability-glycoprotein (Pgp) is a drug transporter responsible for the efflux of xenobiotics
out of cells that influence the pharmacokinetics of numerous drugs. However, the role of this …

Authored by renowned leaders in the field, this comprehensive volume covers all aspects of
drug-drug interactions, including preclinical, clinical, toxicological, and regulatory …

The permeability of biological membranes is one of the most important determinants of the
pharmacokinetic processes of a drug. Although it is often accepted that many drug …

During past decades, knowledge on placental drug metabolism and mechanisms of
placental transfer has increased significantly. Most pharmaceutical drugs administered …

The binding of a drug to serum or plasma proteins enables the transport of drugs via the
blood to sites of action throughout the body. For expediency we will use serum proteins …

Membrane transporters have wide, but specific tissue distributions. They can impact on
multiple endogenous and xenobiotic processes. Knowledge and awareness within the …