Cancer is a heterogeneous and complex disease and one of the leading causes of death
worldwide. The high tumor heterogeneity between individuals affected by the same cancer …

Drug combinations have been proposed to combat drug resistance in cancer, but due to the
large number of possible drug targets, in vitro testing of all possible combinations of drugs is …

Treatment with combinations of drugs carries great promise for personalized therapy for a
variety of diseases. We have previously shown that synergistic combinations of cancer …

Despite a growing body of knowledge on the mechanisms underlying the onset and
progression of cancer, treatment success rates in oncology are at best modest. Current …

Discovery of efficient anti-cancer drug combinations is a major challenge, since
experimental testing of all possible combinations is clearly impossible. Recent efforts to …

Discrete dynamical modeling shows promise in prioritizing drug combinations for screening
efforts by reducing the experimental workload inherent to the vast numbers of possible drug …

Translational models directly relating drug response specific processes that can be
observed in vitro to their in vivo role in cancer patients constitute a crucial part of the …

A central goal of precision oncology is to administer an optimal drug treatment to each
cancer patient. A common preclinical approach to tackle this problem has been to …

Every patient and every disease is different. Each patient therefore requires a personalized
treatment approach. For technical reasons, a personalized approach is feasible for treatment …

Combination therapies are commonly used to treat patients with complex diseases that
respond poorly to single-agent therapies. In vitro high-throughput drug screening is a …