There are many reagents useful for the extension of organic molecules by three carbons
with some functionality at the new terminus. 1 However, to the best of our knowledge, the …

Herein we report the efficient one-and two-carbon homologation of 1° and 2° alcohols to
their corresponding homologated esters via the Mitsunobu reaction using β-carbonyl …

A continuous protocol for the two-carbon homologation of esters to α, β-unsaturated esters is
described. This multireactor homologation telescopes an ester reduction, phosphonate …

An efficient sequence for the one-carbon homologation of aldehydesand ketones to
carboxylic acids 2, esters 3, and amides 4 involves (1) the Horner-Emmons modification of …

Conclusion The major product la is a trans isomer, and the minor product lb is a cis isomer.
The distortion of the pyrrolidinone ring in la causes H3 and H4 to be oriented at a dihedral …

An approach to 1 that has been under exploration in this laboratory features an-ketol
rearrangement to set the bridgehead hydroxyl early in the synthesis3 and a charge …

Tetrahedron Letters,Vol.25,No.33,pp 3647-3648,1984 0040-4039/84 $3.00 + .OO Printed in
Great Britain 81984 Pergamon Press Ltd. l Page 1 Tetrahedron Letters,Vol.25,No.33,pp …

11 12 0 (a) LiAlH „, Et20;(b) Me3SiCl, Nal;(c) Zn/Cu, ether;(d) 2 (1 equiv). to the 1, 2-
dimethylene functionality have been reported. 5 Typically, we have found the diethyl ester …

Phosphonate reagents were developed for the two-carbon homologation of aldehydes or
ketones to unbranched-or methyl-branched α, β-unsaturated aldehydes. The phosphonate …

82 CHO aldehydes and ketones may be converted into a, 8-unsaturated aldehydes or l-
methoxy-1, 3-butadienes with three carbon homologation in good overall yields (see Table) …