While the major architectural features and active-site components of group II introns have
been known for almost a decade, information on the individual stages of splicing has been …

Mechanistic analyses of nuclear pre-mRNA splicing by the spliceosome and group II intron
self-splicing provide insight into both the catalytic strategies of splicing and the evolutionary …

Group I introns are catalytic RNAs capable of orchestrating two sequential
phosphotransesterification reactions that result in self-splicing. To understand how the group …

The identical reaction pathway executed by the spliceosome and self-splicing group II intron
ribozymes has prompted the idea that both may be derived from a common molecular …

Group I and group II introns are two types of RNA enzymes, ribozymes, that catalyze their
own splicing by different mechanisms. In this review, we summarize current information …

Group II introns are large, natural catalytic RNAs or ribozymes that were discovered in
organelles of certain protists, fungi, algae, and plants and more recently also in prokaryotic …

The ai5γ group II intron from yeast excises itself from precursor transcripts in the absence of
proteins. When a shortened form of the intron containing all but the 3 '-terminal six …

Group II introns are Mg2+-dependent ribozymes that are considered to be the evolutionary
ancestors of the eukaryotic spliceosome, thus representing an ideal model system to …

Although group II intron ribozymes are intensively studied the question how structural
dynamics affects splicing catalysis has remained elusive. We report for the first time that the …

Group II introns are self-splicing ribozymes that catalyze their own excision from precursor
transcripts and insertion into new genetic locations. Here we report the crystal structure of an …