By examining the first step of group II intron splicing in the absence of the second step, we
have found that there is an interplay of three distinct reactions at the 5'-splice site: branching …

One largely unexplored question about group I intron splicing is how the cleavage and
ligation steps of the reaction are coordinated. We describe a simple in vitro trans-splicing …

Group I and group II introns are not only catalytic RNAs, but also mobile genetic elements.
The success of these introns as mobile elements almost certainly relates to their innate self …

Group II introns are mobile genetic elements that self-splice and retrotranspose into DNA
and RNA. They are considered evolutionary ancestors of the spliceosome, the …

Group II introns are self‐splicing RNA molecules that are of considerable interest as
ribozymes, mobile genetic elements and examples of folded RNA. Although these introns …

A model for selection of 3′‐splice sites in splicing of RNA precursors containing group I
introns is presented. The key feature of this model is a newly identified tertiary interaction …

Group II introns are self-splicing, mobile genetic elements that have fundamentally
influenced the organization of terrestrial genomes. These large ribozymes remain important …

To understand the behavior of group I introns on a biologically fundamental level, we must
distinguish those traits that arise as the products of natural selection (selected traits) from …

Group II introns are large ribozymes, consisting of six functionally distinct domains that
assemble in the presence of Mg 2+ to the active structure catalyzing a variety of reactions …