Introduction: Leptin is a hormone with a key role in food intake and body weight
homeostasis. Congenital leptin deficiency (CLD) is a rare disease that causes hyperphagia …

Diet-induced obesity and its metabolic comorbidities constitute an overwhelming health
crisis and there is an urgent need for safe and effective pharmacological interventions …

The peptide hormone leptin regulates food intake, body mass, and reproductive function and
plays a role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis …

Leptin is the first identified adipose-tissue-derived cytokine, which exerts profound functions
in the regulation of food intake, energy expenditure, glucose metabolism, reproduction and …

Leptin is a hormone primarily produced by the adipose tissue in proportion to the size of fat
stores, with a primary function in the control of lipid reserves. Besides adipose tissue, leptin …

Leptin is a master regulator of energy balance and body adiposity. Additionally, leptin exerts
important control on glucose homeostasis, thermogenesis, autonomic nervous system and …

Despite significant reductions in the consumption of dietary fat, the prevalence of obesity is
steadily rising in western civilization. Of particular concern is the recent epidemic of …

The adipocyte-derived hormone/cytokine leptin acts as a metabolic switch, connecting the
body's nutritional status to high energy consuming processes such as reproduction and …

Leptin is an adipocyte-derived hormone that primarily acts in the hypothalamus and plays a
key role in the regulation of food intake, body weight, energy expenditure and …

Leptin (from the Greek word “lepto''meaning “thin”) is a 167-amino acid peptide hormone
encoded by the obesity (ob) gene and secreted by white adipocytes. Blood leptin …