Alterations in sphingolipid metabolism are described to contribute to various neurological
disorders. We here determined the expression of enzymes involved in the sphingomyelin …

The SARS‐CoV‐2 infection cycle is a multistage process that relies on functional
interactions between the host and the pathogen. Here, we repurposed antiviral drugs …

Ceramide, the precursor of all complex sphingolipids, is a potent signaling molecule that
mediates key events of cellular pathophysiology. In the nervous system, the sphingolipid …

Ceramide is a core molecule of sphingolipid metabolism that causes selective insulin
resistance and dyslipidemia. Research on its involvement in cardiovascular diseases has …

Altered levels of sphingolipids and their metabolites in the brain, and the related
downstream effects on neuronal homeostasis and the immune system, provide a framework …

Our understanding of the functions of ceramide signaling has advanced tremendously over
the past decade. In this review, we focus on the roles and regulation of neutral …

Major depressive disorder (MDD) is a common and severe disease characterized by mood
changes, somatic alterations, and often suicide. MDD is treated with antidepressants, but the …

Sphingolipids represent a class of diverse bioactive lipid molecules that are increasingly
appreciated as key modulators of diverse physiologic and pathophysiologic processes that …

One of the most intriguing enzymes of sphingolipid biology is acid sphingomyelinase
(ASMase). In a phospholipase C reaction, ASMase catalyzes the cleavage of the …

Fluvoxamine is a well-tolerated, widely available, inexpensive selective serotonin reuptake
inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized …