Farber disease (FD) is a severe inherited disorder of lipid metabolism characterized by
deficient lysosomal acid ceramidase (ACDase) activity, resulting in ceramide accumulation …

Diabetes mellitus (DM) is a systemic metabolic disease that affects 463 million adults
worldwide and is a leading cause of cardiovascular disease, blindness, nephropathy …

S-acylation, also known as palmitoylation, is the most widely prevalent form of protein
lipidation, whereby long-chain fatty acids get attached to cysteine residues facing the …

Nitric oxide and reactive oxygen species play a critical role in photoreceptor apoptosis.
However, the exact molecular mechanisms triggered by oxidative stress in photoreceptor …

Sphingolipids including ceramide and its derivatives such as ceramide-1-phosphate,
glycosyl-ceramide, and sphinogosine (-1-phosphate) are now recognized as novel …

In line with SARS and MERS, the SARS-CoV-2/COVID-19 pandemic is one of the largest
challenges in medicine and health care worldwide. SARS-CoV-2 infection/COVID-19 …

Compound repurposing is an important strategy for the identification of effective treatment
options against SARS-CoV-2 infection and COVID-19 disease. In this regard, SARS-CoV-2 …

Diabetes mellitus is a metabolic disease with multiple complications that causes serious
diseases over the years. The condition leads to severe economic consequences and is …

Macrodomains are a class of conserved ADP-ribosylhydrolases expressed by viruses of
pandemic concern, including coronaviruses and alphaviruses. Viral macrodomains are …

The SARS-CoV-2 main protease (Mpro) is a medicinal chemistry target for COVID-19
treatment. Given the clinical efficacy of β-lactams as inhibitors of bacterial nucleophilic …