Perceptual correlates of nociceptive long-term potentiation and long-term depression in humans

T Klein, W Magerl, HC Hopf, J Sandkühler… - Journal of …, 2004 - Soc Neuroscience
Long-term potentiation (LTP) and long-term depression (LTD) of synaptic strength are
ubiquitous mechanisms of synaptic plasticity, but their functional relevance in humans …

The role of heterosynaptic facilitation in long-term potentiation (LTP) of human pain sensation

T Klein, S Stahn, W Magerl, RD Treede - Pain, 2008 - Elsevier
Long-term potentiation (LTP) of nociceptive synaptic transmission induced by high-
frequency electrical stimulation (HFS) predominantly modulates natural somatosensory …

Analysis of hyperalgesia time courses in humans after painful electrical high-frequency stimulation identifies a possible transition from early to late LTP-like pain …

DB Pfau, T Klein, D Putzer, EM Pogatzki-Zahn… - PAIN®, 2011 - Elsevier
Electrical high-frequency stimulation (HFS) of skin afferents elicits long-term potentiation
(LTP)-like hyperalgesia in humans. Time courses were evaluated in the facilitating …

Modality-specific sensory changes in humans after the induction of long-term potentiation (LTP) in cutaneous nociceptive pathways

S Lang, T Klein, W Magerl, RD Treede - Pain, 2007 - Elsevier
The impact of long-term potentiation (LTP) in nociceptive pathways on somatosensory
perception was examined by means of quantitative sensory testing (QST) in the ventral …

Induction of long‐term potentiation at spinal synapses by noxious stimulation or nerve injury

J Sandkühler, X Liu - European Journal of Neuroscience, 1998 - Wiley Online Library
Use‐dependent long‐term potentiation of synaptic strength (LTP) is an intensively studied
model for learning and memory in vertebrates. Induction of LTP critically depends on the …

Understanding LTP in pain pathways

J Sandkühler - Molecular pain, 2007 - journals.sagepub.com
Long-term potentiation (LTP) at synapses of nociceptive nerve fibres is a proposed cellular
mechanism underlying some forms of hyperalgesia. In this review fundamental properties of …

Capsaicin-sensitive C-and A-fibre nociceptors control long-term potentiation-like pain amplification in humans

F Henrich, W Magerl, T Klein, W Greffrath, RD Treede - Brain, 2015 - academic.oup.com
Long-term potentiation in the spinal dorsal horn requires peptidergic C-fibre activation in
animals. Perceptual correlates of long-term potentiation following high-frequency electrical …

Long-Term Potentiation at C-Fibre Synapses by Low-Level Presynaptic Activity in vivo

R Drdla, J Sandkühler - Molecular pain, 2008 - journals.sagepub.com
Inflammation, trauma or nerve injury trigger low-level activity in C-fibres and may cause long-
lasting hyperalgesia. Long-term potentiation (LTP) at synapses of primary afferent C-fibres is …

Differential effects of tactile high-and low-frequency stimulation on tactile discrimination in human subjects

P Ragert, T Kalisch, B Bliem, S Franzkowiak… - BMC neuroscience, 2008 - Springer
Background Long-term potentiation (LTP) and long-term depression (LTD) play important
roles in mediating activity-dependent changes in synaptic transmission and are believed to …

[HTML][HTML] Hyperalgesia by synaptic long-term potentiation (LTP): an update

J Sandkühler, D Gruber-Schoffnegger - Current opinion in pharmacology, 2012 - Elsevier
Long-term potentiation of synaptic strength (LTP) in nociceptive pathways shares principle
features with hyperalgesia including induction protocols, pharmacological profile, neuronal …