Fatty acid biosynthesis is essential for bacterial survival. FabH, β-ketoacyl-acyl carrier
protein (ACP) synthase III, is a particularly attractive target, since it is central to the initiation …

Our current work is aimed at synthesizing novel derivatives of 1, 2, 3–triazolyl–indazoles,
applying docking techniques and biological evaluation in order to find active promising …

In this study, we have designed and synthesized 2-((5-acetyl-1-(phenyl)-4-methyl-1H-
imidazol-2-yl) thio)-N-(4-((benzyl) oxy) phenyl) acetamide derivatives. Antimicrobial activities …

Recently, the emergence and spread of pathogenic bacterial resistance to many antibiotics
(multidrug-resistant strains) have been increasing throughout the world. This phenomenon …

A library of six novel bis-Schiff base derivatives (2a-f) were synthesized, characterized
through modern spectroscopic techniques and screened for their α-glucosidase and α …

The indolones nucleus is the central core to develop new effective anticancer agents and its
substitution at the 3-position can affect antitumor activity, 3-spirocyclopropyl-2-oxindoles …

The InhA inhibitors play key role in mycolic acid synthesis by preventing the fatty acid
biosynthesis pathway. In this present article, Pharmacophore modelling and molecular …

A series of novel (2-oxoindolin-3-ylidene) methyl)-1H-pyrazole and their fused derivatives
bearing oxindole moiety have been designed and successfully synthesized to and …

E. coli is a Gram-negative bacterium that causes different human infections. Additionally, it
resists common antibiotics due to its outer protective membrane. Natural products have …

Abstract In this study,(z)-5-((3-(2, 3-dihydroxyphenyl) acryloyl) oxy)-1, 3, 4-
trihydroxycyclohexa-2, 4-diene-1-carboxylic acid (chlorogenic acid) was isolated and …