Keeping in view various pharmacological attributes of indole and coumarin derivatives, a
new series of indolindione–coumarin molecular hybrids was rationally designed and …

In this study, a novel series of oxazoline and thiazoline were designed as inhibitors of
cytochrome P450 14 alpha-sterol demethylase (CYP51) from Candida albicans and peptide …

Components of fatty acid biosynthetic pathway have been identified as attractive targets for
the development of new antibacterial agents. Compounds of series A (4a–4g) and series B …

Bacterial survival depends on membrane lipid homeostasis that enables to regulate lipid
composition to adapt and optimize their growth in diverse environments. Therefore, the …

The development of effective antibacterial agents equipped with novel action modes and
unique skeletons starting from natural compounds serves as an important strategy in the …

Rapidly growing antimicrobial resistance among clinically important bacterial and fungal
pathogens accounts for high morbidity and mortality worldwide. Therefore, it is critical to look …

In an effort to establish new drug candidates with improved antimicrobial and anticancer
activities, we report here synthesis, molecular modeling, and in vitro biological evaluation of …

Infectious diseases are a major concern around the world. Today, it is an urgent need for
new chemotherapeutics for infectious diseases. Because of that, our group designed …

Novel series of long chain isoxazole derivatives were designed as inhibitors of Cytochrome
P450-14DM14a-demethylase from Candida albicans and ribosomal subunit of S12 protein …

Nimbolide, a tetranortriterpenoid (limonoid) compound isolated from the leaves of
Azadirachta indica, was screened both in vitro and in silico for its antimicrobial activity …